About
Contact & Profiles
A5106254106
Research Areas
- CRISPR and Genetic Engineering
- Genetic Neurodegenerative Diseases
- Pluripotent Stem Cells Research
University of Milan
2024
Huntington's disease (HD) causes selective degeneration of striatal and cortical neurons, resulting in cell mosaicism coexisting still functional dysfunctional cells. The impact non-cell autonomous mechanisms between these cellular states is poorly understood. Here we generated telencephalic organoids with healthy or HD cells, grown separately as mosaics the two genotypes. Single-cell RNA sequencing revealed neurodevelopmental abnormalities ventral fate acquisition organoids, confirmed by...
10.1038/s41467-024-50877-x
article
EN
cc-by-nc-nd
Nature Communications
2024-08-02
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