A5047596847- Venomous Animal Envenomation and Studies
- Amphibian and Reptile Biology
- Marine Invertebrate Physiology and Ecology
- Rabies epidemiology and control
- Insect and Pesticide Research
- Antimicrobial Peptides and Activities
- Bird parasitology and diseases
- Animal Ecology and Behavior Studies
- Insect and Arachnid Ecology and Behavior
- Neurobiology and Insect Physiology Research
- Biochemical and Structural Characterization
- Identification and Quantification in Food
Justus-Liebig-Universität Gießen
2023-2024
Fraunhofer Institute for Molecular Biology and Applied Ecology
2022-2024
LOEWE Centre for Translational Biodiversity Genomics
2022-2024
Snake venom is an ecologically critical functional trait, primarily applied for foraging and accordingly shaped by selective pressures. Recent insights underpinned the high variability of snake venoms down to intraspecific level, with regional, ontogenetic, seasonal variation being mostly investigated. In contrast, sex-based has received considerably less attention so far, its influence on compositions in vipers virtually unknown. The common adder ( Vipera berus ) a promising model species...
Introduction: Snakebite is a neglected tropical disease and globally important driver of death morbidity. Vipers the genus Macrovipera (Viperidae: Viperinae) are among snakes higher medical importance in Old World. Despite relevance venoms, knowledge regarding them heterogeneously distributed with virtually all works conducted so far focusing on subspecies lebetinus, while other species within largely overlooked. Here we present first proteomic evaluation venom from Greek endemic Milos viper...
Snakebite primarily impacts rural communities of Africa, Asia, and Latin America. The sharp-nosed viper (Deinagkistrodon acutus) is among the snakes highest medical importance in Asia. Despite various studies on its venom using modern venomics techniques, a comprehensive understanding composition function this species' remains lacking. We combined proteogenomics with extensive bioactivity profiling to present first genome-level catalogue D. acutus proteins their exochemistry. Our analysis...
The venoms of ants (Formicidae) are a promising source novel bioactive molecules with potential for clinical and agricultural applications. However, despite the rich diversity ant species, only fraction this vast resource has been thoroughly examined in bioprospecting programs. Previous studies focusing on venom Central European (subfamily Myrmicinae) identified number short linear decapeptides nonapeptides resembling antimicrobial peptides (AMPs). Here, we describe silico approach...
The venoms of spiders from the RTA (retro-lateral tibia apophysis) clade contain diverse short linear peptides (SLPs) that offer a rich source therapeutic candidates. Many these have insecticidal, antimicrobial and/or cytolytic activities, but their biological functions are unclear. Here, we explore bioactivity all known members A-family SLPs previously identified in venom Chinese wolf spider (Lycosa shansia). Our broad approach included an silico analysis physicochemical properties and...
Snake venom is an ecologically relevant functional trait directly linked with a snake’s fitness and survival, facilitating predation defence. variation occurs at all taxonomic levels, but the study intraspecific level still in its early stages. The common adder ( Vipera berus ) exhibits considerable colour phenotypes across distribution range. Melanistic (fully black) individuals are subject of myths fairytales, German folklore such ‘hell adders’ considered more toxic than their normally...
1 Abstract Snake venom is an ecologically-relevant functional trait directly linked with a snake’s fitness and survival, facilitating predation defense. variation occurs at all taxonomic levels, but the study of intraspecific level still in its early stages. The common adder ( Vipera berus ) exhibits considerable color phenotypes across distribution range. Melanistic (fully black) individuals are subject myths fairytales, German folklore such “hell adders” considered more toxic than their...
“True” cobras (genus Naja) are among the venomous snakes most frequently involved in snakebite accidents Africa and Asia. The Cape cobra (Naja nivea) is one of African highest medical importance, but much remains to be learned about its venom. Here, we used a shotgun proteomics approach better understand qualitative composition N. nivea venom tested cytotoxicity protease activity as well effect on intracellular Ca2+ release NO synthesis. We identified 156 components representing 17 protein...