A5008577429- Genomics and Chromatin Dynamics
- RNA Research and Splicing
- Developmental Biology and Gene Regulation
- Cellular Mechanics and Interactions
- Constructed Wetlands for Wastewater Treatment
Princeton University
2019-2023
Partitioning of mRNAs into ribonucleoprotein (RNP) granules supports diverse regulatory programs within the crowded cytoplasm. At least two types RNP populate germ plasm, a cytoplasmic domain at posterior Drosophila oocyte and embryo. Germ deliver required for germline development to pole cells, cell progenitors. A second type granule, here named founder granules, contains oskar mRNA, which encodes plasm organizer. Whereas mRNA is essential assembly during oogenesis, we show that it toxic...
Localization of oskar mRNA to the posterior Drosophila oocyte is essential for abdominal patterning and germline development. localization a multi-step process involving temporally mechanistically distinct transport modes. Numerous cis-acting elements trans-acting factors have been identified that mediate earlier motor-dependent steps leading an initial accumulation at posterior. Little known, however, about requirements later phase, which depends on cytoplasmic flows results in large...
ABSTRACT Localization of oskar mRNA to the posterior Drosophila oocyte is essential for abdominal patterning and germline development. localization a multi-step process involving temporally mechanistically distinct transport modes. Numerous cis-acting elements trans-acting factors have been identified that mediate earlier motor-dependent steps leading accumulation at posterior. Little known, however, about what features are required later phase, occurs by diffusion with local entrapment...