A5102943746- Immune Cell Function and Interaction
- Birth, Development, and Health
- Genetics and Neurodevelopmental Disorders
- T-cell and B-cell Immunology
- Obesity, Physical Activity, Diet
- RNA Research and Splicing
- Influenza Virus Research Studies
- Retinoids in leukemia and cellular processes
- Estrogen and related hormone effects
- Mesenchymal stem cell research
- Child Nutrition and Water Access
- Hong Kong and Taiwan Politics
- Gestational Diabetes Research and Management
- Periodontal Regeneration and Treatments
- Gout, Hyperuricemia, Uric Acid
- Ion Channels and Receptors
- Digital Marketing and Social Media
- Microtubule and mitosis dynamics
- Telomeres, Telomerase, and Senescence
- Heterotopic Ossification and Related Conditions
- Erythrocyte Function and Pathophysiology
- Regulation of Appetite and Obesity
- Traumatic Brain Injury and Neurovascular Disturbances
- Lysosomal Storage Disorders Research
- Connexins and lens biology
Peking University People's Hospital
2023-2025
Peking University
2016-2025
Taixing People's Hospital
2025
Princeton University
1998-2023
Tsinghua University
2010-2023
Chinese Institute for Brain Research
2023
Shanghai Tenth People's Hospital
2021
Legacy Health
2021
Guangzhou University
2021
Shandong Center for Disease Control and Prevention
2021
We study the "entanglement spectrum" (a presentation of Schmidt decomposition analogous to a set "energy levels") many-body state, and compare Moore-Read model wave function for nu=5/2 fractional quantum Hall state with generic 5/2 obtained by finite-size diagonalization second-Landau-level-projected Coulomb interactions. Their spectra share common "gapless" structure, related conformal field theory. In these are only levels, while in "generic" case, they separated from rest spectrum clear...
Allotype and isotype exclusion is a property of most lymphocytes. The reason for this not known but it guarantees high concentration single receptor, threshold numbers receptors may be required efficient positive negative selection. Receptor editing compromises by sustaining recombination even after functional receptor formed. Consequently, B cells expressing multiple arise. We have studied such in which one the two anti-self, find that these partially autoreactive accumulate marginal zone....
We have studied the regulation of anti–DNA B cells in transgenic mice with a heavy chain transgene (3H9H/56R). This codes for that forms anti–double-stranded DNA (dsDNA) antibody when paired most members endogenous Vκ repertoire, but certain L chains, referred to as editors, do not sustain dsDNA binding combination 3H9H/56R. In nonautoimmune 3H9H/56R BALB/c, generated bind because itself is edited or associated editor. A minor population (30%) and express λ1 light (known binding). These...
Anti-DNA antibodies are regulated in normal individuals but found high concentration the serum of systemic lupus erythematosus (SLE) patients and MRL lpr/lpr mouse model SLE. We previously studied regulation anti–double-stranded (ds)DNA anti–single-stranded (ss)DNA B cells a nonautoimmune background by generating mice carrying immunoglobulin transgenes coding for anti-DNAs derived from lpr/lpr. Anti-dsDNA undergo receptor editing, anti-ssDNA seem to be functionally silenced. Here we have...
Objective To examine the associations between dietary zinc intake and hyperuricaemia. Design Cross-sectional study. Setting This study was conducted in a health examination centre of China. Participants A total 5168 middle-aged older participants (aged 40 years or above) (2697 men 2471 women) were included. Outcome measures Dietary assessed using validated semiquantitative food frequency questionnaire. Hyperuricaemia defined as uric acid ≥416 µmol/L for males ≥360 females. Results For males,...
Men who have sex with men (MSM), a population bearing the greatest HIV burden in many countries, may also be vulnerable to COVID-19. COVID-19 vaccines are essential containing pandemic. However, vaccine hesitancy compromise coverage. We aimed understand uptake of and factors associated among HIV-infected MSM mainland China.A cross-sectional online survey was conducted between 13 21 February 2021 China. Variables including demographics, mental health status, characteristics, knowledge...
To determine the risk factors for poor prognosis of influenza-associated encephalopathy (IAE), 56 eligible children with IAE who were treated in pediatric intensive care unit Wuhan Children's Hospital from January 2022 to December 2023 selected retrospective analysis and grouped according or not, independent found by regression analysis. Results showed 26 (26/30, 46.4%) had a prognosis. In univariate analysis, group compared clinically cured significant increase number days hospitalization...
The reference charts of sitting height (SH), subischial leg length (LL) and the height/leg ratio (SH/LL) are useful tools in assessing body proportion for clinicians researchers related areas. However, proportions Chinese children adolescents limited.To construct SH, LL SH/LL adolescents.Stature 92 494 (46 240 boys 46 254 girls) healthy Han nationality children, aged 0-18 years, were measured two national large-scale cross-sectional surveys 2005 China. was selected as indicator proportion....
Localization of oskar mRNA to the posterior Drosophila oocyte is essential for abdominal patterning and germline development. localization a multi-step process involving temporally mechanistically distinct transport modes. Numerous cis-acting elements trans-acting factors have been identified that mediate earlier motor-dependent steps leading an initial accumulation at posterior. Little known, however, about requirements later phase, which depends on cytoplasmic flows results in large...
Steroid and nuclear receptor coactivators (NCoAs) have been implicated in the regulation of function by enhancing ligand-dependent transcriptional activation target gene expression. We previously isolated receptor-associated coactivator 3 (RAC3), which belongs to steroid family. In this study, we investigated differential mechanisms RAC3 interacts with modulates activity different receptors. found that vitamin D (VDR) estrogen β interact α-helical LXXLL motifs RAC3. Peptides corresponding...
Mobile entertainment services are rapidly and widely developing. However, in emerging markets like Chinese rural area, related still not fully accepted by mobile phone users. This primary research aimed to study people's acceptance for entertainment, provide comprehensive models, explain the problem from its socio-economic roots. Interview survey data were collected. Using explorative factor analysis method, two models built: one people North China other East China. The show that "social...
This study aimed to understand the acceptability of short message service (SMS) as a reminder for improving antiretroviral therapy (ART) adherence and determine factors associated with willingness accept SMS among people living HIV (PLH) in China. A total 801 adult patients were recruited cross-sectional survey. Factors unadjusted analyses (α = 0.10) included logistic regression model; 88.4% participants owned mobile phones, 49.6% read every 16.2% only if phone number was familiar, 79.5%...
It is important to update weight-for-length/height growth curves in China and re-examine their performance screening malnutrition.To develop for Chinese children adolescents.A total of 94 302 aged 0-19 years with complete sex, age, weight length/height data were obtained from two cross-sectional large-scaled national surveys China. Weight-for-length/height constructed using the LMS method before after average spermarcheal/menarcheal ages, respectively. Screening prevalence estimates wasting,...
Three cases of avian influenza virus H10N8 were reported in Nanchang, China, as April 2014. To identify the knowledge, attitudes, and practices (KAP) related to among farmers’ market workers, a cross-sectional survey was conducted 63 markets Nanchang. Using resulting data, characteristics poultry non-poultry workers’ practice described. Results suggest that interventions targeting high-risk workers should be developed implemented by public health agencies prevent spread H10N8. Additionally...
Abstract Mice with a keratinocyte-restricted deletion of the actin polymerization–promoting molecule, N-WASP, display cyclic hair loss and skin inflammation. Here, we showed that these mice were also resistant to 7,12-dimethylbenz(a)anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA)–induced tumor formation. This resistance correlated decreased expression senescence regulator, DNMT1, increased marker, p16Ink4a, in N-WASP–deficient epidermis. Moreover, primary N-WASP–null...
Mechanoreceptor cells develop specialized mechanosensory organelles (MOs), where force-sensitive channels and supporting structures are organized in an orderly manner to detect forces. It is intriguing how MOs formed. Here, we address this issue by studying the of fly ciliated mechanoreceptors. We show that main structure a compound cytoskeleton formed short microtubules electron-dense materials (EDMs). In knock-out mutant DCX-EMAP, nearly absent, suggesting DCX-EMAP required for formation...
Nonunions and delayed unions pose significant challenges in orthopedic treatment, with current therapies often proving inadequate. Bone tissue engineering (BTE), particularly through endochondral ossification (ECO), emerges as a promising strategy for addressing critical bone defects. This study introduces mesenchymal stem cells overexpressing Exendin-4 (MSC-E4), designed to modulate remodeling via their autocrine paracrine functions. We established type I collagen (Col-I) sponge-based vitro...
Research in developed countries has found that paternal involvement positive and significant effects on early childhood development (ECD). Less is known, however, about the state of its influence ECD rural China. Using data collected Southern China included 1,460 children aged 6–42 months their fathers (as well as primary caregivers), this study examines association between ECD. Although results demonstrate average level low China, related to a increase three domains (cognition, language,...
Abstract MicroRNAs are enriched in neurons and play important roles dendritic spine development synaptic plasticity. MicroRNA activity is controlled by a wide range of RNA-binding proteins. FMRP, highly conserved protein, has been linked to microRNA-mediated gene regulation axonal formation. FMRP also participates arbor morphogenesis, but whether how microRNAs contribute its function this process remains be elucidated. Here, using Drosophila larval sensory neurons, we show that...