A5100325728- Lung Cancer Treatments and Mutations
- Underwater Acoustics Research
- Underwater Vehicles and Communication Systems
- Cancer therapeutics and mechanisms
- Lung Cancer Research Studies
- Speech and Audio Processing
- Ultrasonics and Acoustic Wave Propagation
- Direction-of-Arrival Estimation Techniques
- Cancer Mechanisms and Therapy
- Data Visualization and Analytics
- Network Security and Intrusion Detection
- Chronic Myeloid Leukemia Treatments
- Gastric Cancer Management and Outcomes
- Neural Networks and Reservoir Computing
- Water Quality Monitoring Technologies
- Indoor and Outdoor Localization Technologies
- Cancer, Hypoxia, and Metabolism
- Dielectric materials and actuators
- RFID technology advancements
- Colorectal Cancer Treatments and Studies
- Heat Transfer Mechanisms
- Sarcoma Diagnosis and Treatment
- Engineering Technology and Methodologies
- Chronic Lymphocytic Leukemia Research
- Data Stream Mining Techniques
Northwestern Polytechnical University
2023-2024
Ludong University
2023
Ariadne Diagnostics (United States)
2015-2023
Shanghai University of Engineering Science
2022
Beijing University of Posts and Telecommunications
2012
In the treatment of echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase positive (ALK+) non-small-cell lung cancer (NSCLC), secondary mutations within ALK domain have emerged as a major resistance mechanism to both first- and second-generation inhibitors. This report describes design synthesis series 2,4-diarylaminopyrimidine-based potent selective inhibitors culminating in identification investigational clinical candidate brigatinib. A unique structural...
Abstract Purpose: Non–small cell lung cancers (NSCLCs) harboring ALK gene rearrangements (ALK+) typically become resistant to the first-generation anaplastic lymphoma kinase (ALK) tyrosine inhibitor (TKI) crizotinib through development of secondary resistance mutations in or disease progression brain. Mutations that confer second-generation TKIs ceritinib and alectinib have also been identified. Here, we report structure first comprehensive preclinical evaluation next-generation TKI...
Abstract Purpose: KIT is the major oncogenic driver of gastrointestinal stromal tumors (GIST). Imatinib, sunitinib, and regorafenib are approved therapies; however, efficacy often limited by acquisition polyclonal secondary resistance mutations in KIT, with those located activation (A) loop (exons 17/18) being particularly problematic. Here, we explore KIT-inhibitory activity ponatinib preclinical models describe initial characterization its patients GIST. Experimental Design: The cellular...
Lactate dehydrogenase A (LDH-A) catalyzes the interconversion of lactate and pyruvate in glycolysis pathway. Cancer cells rely heavily on instead oxidative phosphorylation to generate ATP, a phenomenon known as Warburg effect. The inhibition LDH-A by small molecules is therefore interest for potential cancer treatments. We describe identification optimization inhibitors fragment-based drug discovery. applied ligand based NMR screening identify low affinity fragments binding LDH-A....
Hydrogels exhibit ideal flexibility and biocompatibility, which have attracted the attention of many researchers in field flexible electronics. However, challenge exists to endow hydrogel sensors with higher strength, stretchability, excellent self-healing efficiency, wide application temperature range. Herein, a stretchable, conductive, antifreeze, was prepared by implanting polyaniline (PANI)-coated cellulose nanocrystals (CNCs) betaine into gellan gum (GG)/poly(acrylic acid) (PAA) hybrid...
Abstract Phosphorus, despite its abundance in the human body, is rarely found drug molecules, with clinical utility limited to a few phosphonic or bisphosponic acid-based medicines and several phosphonate phosphate-containing prodrugs. Concerns about poor cell penetration, low oral bioavailability, biological instability have application of these functional classes design. In our efforts discover pharmaceuticals novel functionality, we introduced neutral, stable phosphine oxide moiety as...
To improve the performance of sonar system mounted on underwater unmanned platform, beam control method compact acoustic transmitting transducer array is studied. For a composed close-packed transducers, many factors can affect directivity, such as position deviation and difference each element, scattering, occlusion effect, mutual coupling among elements, so on. solve this problem, we derive steering vector, propose global optimization to design patterns array, it via second-order cone...
Gridless direction of arrival (DOA) estimation methods have garnered significant attention due to their ability avoid grid mismatch errors, which can adversely affect the performance high-resolution DOA algorithms. However, most existing gridless are primarily restricted applications involving uniform linear arrays or sparse arrays. In this paper, we derive relationship between element-domain covariance matrix and angular-domain for arbitrary array geometries by expanding steering vector...
Deep-sea transducers are of great significance for improving the performance sonar, and we cannot greatly improve piezoelectric ceramic through structural optimization without increasing their size. To solve this problem, use relaxor ferroelectric single crystal to design longitudinal vibration cavity resonant coupling transducer, which couples performance. First, transducer structure is designed withstand high hydrostatic pressure. Then, finite element method used analyze influence metal...
Nowadays, massive data continues to produce, which increases the scale of database tables, a lot performance problems come with procedure updating tables. In this paper, solve these problems, we propose new solutions based on Oracle RowID. way, can update tables quickly. On basis studying structure block and RowID, choose flow dataset test our solutions. The results show that significantly shorten execution time, reduce occupation system resources.
<div>Abstract<p><b>Purpose:</b> Non–small cell lung cancers (NSCLCs) harboring <i>ALK</i> gene rearrangements (ALK<sup>+</sup>) typically become resistant to the first-generation anaplastic lymphoma kinase (ALK) tyrosine inhibitor (TKI) crizotinib through development of secondary resistance mutations in ALK or disease progression brain. Mutations that confer second-generation TKIs ceritinib and alectinib have also been identified. Here, we...
The directivity of the transmitting transducer may affect signal-to-noise ratio (SNR) receiver, which has a great influence on performance acoustic communication system. In order to study relationship between them, factors that SNR at receiving end are clarified, and transmission loss beam width is simulated. Then, deep-sea mosaic free-flooded ring wide vertical can resist high hydrostatic pressure designed manufactured. measurement system set up in anechoic tank measured. Finally, OFDM...
To satisfy the requirement of underwater target detection and recognition, acoustic communication, marine environmental parameter measurement, this paper designs a programmable sound source system applied to deep sea. The passive sonar equation is used analyze relationship between transmitting distance operating frequency system. Then, it proposed use robust communication technology realize adjustment parameters such as type transmitted signal, power, mode A low also designed manufactured,...