A5061927525- Protein Kinase Regulation and GTPase Signaling
- 14-3-3 protein interactions
- Microtubule and mitosis dynamics
- Cell Adhesion Molecules Research
- Cellular Mechanics and Interactions
- CAR-T cell therapy research
University of Pennsylvania
2025
University of Georgia
2023
University of Liverpool
2023
Abstract To overcome the paucity of known tumor-specific surface antigens in pediatric high-grade glioma (pHGG), we contrasted splicing patterns pHGGs and normal brain samples. Among alternative events affecting extracellular protein domains, most pervasive alteration was skipping ≤30 nucleotide-long microexons. Several these skipped microexons mapped to L1-IgCAM family members, such as NRCAM . Bulk single-nuclei short- long-read RNA-seq revealed uniform 5 19 virtually every pHGG sample....
Catalytic signaling outputs of protein kinases are dynamically regulated by an array structural mechanisms, including allosteric interactions mediated intrinsically disordered segments flanking the conserved catalytic domain. The doublecortin-like (DCLKs) a family microtubule-associated proteins characterized flexible C-terminal autoregulatory 'tail' segment that varies in length across various human DCLK isoforms. However, mechanism whereby these isoform-specific variations contribute to...
Catalytic signaling outputs of protein kinases are dynamically regulated by an array structural mechanisms, including allosteric interactions mediated intrinsically disordered segments flanking the conserved catalytic domain. The Doublecortin Like Kinases (DCLKs) a family microtubule-associated proteins characterized flexible C-terminal autoregulatory 'tail' segment that varies in length across various human DCLK isoforms. However, mechanism whereby these isoform-specific variations...
Catalytic signaling outputs of protein kinases are dynamically regulated by an array structural mechanisms, including allosteric interactions mediated intrinsically disordered segments flanking the conserved catalytic domain. The Doublecortin Like Kinases (DCLKs) a family microtubule-associated proteins characterized flexible C-terminal autoregulatory ‘tail’ segment that varies in length across various human DCLK isoforms. However, mechanism whereby these isoform-specific variations...
Catalytic signaling outputs of protein kinases are dynamically regulated by an array structural mechanisms, including allosteric interactions mediated intrinsically disordered segments flanking the conserved catalytic domain. The Doublecortin Like Kinases (DCLKs) a family microtubule-associated proteins characterized flexible C-terminal autoregulatory ‘tail’ segment that varies in length across various human DCLK isoforms. However, mechanism whereby these isoform-specific variations...
Catalytic signaling outputs of protein kinases are dynamically regulated by an array structural mechanisms, including allosteric interactions mediated intrinsically disordered segments flanking the conserved catalytic domain. The doublecortin-like (DCLKs) a family microtubule-associated proteins characterized flexible C-terminal autoregulatory ‘tail’ segment that varies in length across various human DCLK isoforms. However, mechanism whereby these isoform-specific variations contribute to...