Léa Saban-Roche

ORCID: 0009-0008-6375-2839
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About
Contact & Profiles
Research Areas
  • Ear and Head Tumors
  • Colorectal Cancer Treatments and Studies
  • Head and Neck Cancer Studies
  • Lung Cancer Research Studies
  • Medication Adherence and Compliance
  • Head and Neck Surgical Oncology
  • Genetic factors in colorectal cancer
  • Neuroendocrine Tumor Research Advances
  • Gestational Trophoblastic Disease Studies
  • COVID-19 and healthcare impacts
  • Hepatocellular Carcinoma Treatment and Prognosis
  • Cancer Diagnosis and Treatment
  • COVID-19 Clinical Research Studies
  • Cancer Treatment and Pharmacology
  • Neurological Complications and Syndromes
  • Acute Lymphoblastic Leukemia research
  • Healthcare cost, quality, practices
  • Cancer and Skin Lesions
  • Pharmaceutical Practices and Patient Outcomes
  • Neurological and metabolic disorders
  • Childhood Cancer Survivors' Quality of Life
  • Moyamoya disease diagnosis and treatment
  • Lung Cancer Treatments and Mutations
  • Head and Neck Anomalies
  • Colorectal and Anal Carcinomas

Institute Cancer De La Loire Lucien Neuwirth
2008-2024

Cancer Institute (WIA)
2010

Institut de Cancérologie de l'Ouest
2008

Conventional radiotherapy with concurrent cisplatin is significantly superior to induction fluorouracil chemotherapy followed by in terms of laryngeal preservation patients T3 hypopharyngeal carcinoma. Despite a high rate no survival benefit was recorded this selected population.To compare conventional radiotherapy. The primary end point the larynx. secondary points included toxicity, causes death, and rates.Seventy-one adult previously untreated resectable pyriform sinus squamous cell...

10.3109/00016480902914080 article EN Acta Oto-Laryngologica 2010-01-01

A pretreatment neck dissection in a chemoradiation regimen for pyriform sinus carcinoma provides no delay radiation, low complication rates, optimal radiation doses and high nodal disease control.The aims of this study were to evaluate the clinical feasibility, therapeutic consequences nodes control organ preservation strategy carcinoma.Seventy-six patients with untreated stage III IV squamous cell included study. Eighty dissections performed according N status. Dose radiotherapy was...

10.1080/00016480701477669 article EN Acta Oto-Laryngologica 2008-01-01

Patients with RAS wild-type (WT) nonresectable metastatic colorectal cancer (mCRC) may receive either bevacizumab or an anti-epidermal growth factor receptor (EGFR) combined first-line, 5-fluorouracil-based chemotherapy. Without the status information, oncologist can start chemotherapy wait for introduction of anti-EGFR. Our objective was to compare both strategies in a routine practice setting.This multicenter, retrospective, propensity score-weighted study included patients WT mCRC,...

10.1634/theoncologist.2019-0328 article EN cc-by-nc-nd The Oncologist 2019-10-02

Alkylating agents (ALKY) are the main chemotherapies used for advanced neuroendocrine tumors (NETs). O6-Methylguanine-DNA methyltransferase (MGMT) status, as proficient (p) or deficient (d), may predict response to ALKY. MGMT-NET (ClinicalTrials.gov identifier: NCT03217097) was a phase II trial randomly assigning 1:1 pMGMT 2:1 dMGMT-NETs either ALKY oxaliplatin (Ox). Inclusion criteria were confirmed pancreatic, thoracic, unknown primary NETs with an indication chemotherapy and tissue...

10.1200/jco.23.02724 article EN Journal of Clinical Oncology 2024-11-25

e16221 Background: Aim of our study was to assess the interest induction chemotherapy (ICT) intensification before chemoradiotherapy (CRT) in patients with locally advanced pancreatic cancer Methods: All treated between February 2010 and November 2016 CRT (total dose: 50 Gy; Capecitabine: 830 mg/m2 twice daily) were included this bicentric study. Patients who underwent Gemcitabine as ICT (Group G) compared intensive such Folforinox or GemOx (group I). Data collected retrospectively. The...

10.1200/jco.2018.36.15_suppl.e16221 article EN Journal of Clinical Oncology 2018-05-20
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