A5011078194- Tissue Engineering and Regenerative Medicine
- Muscle Physiology and Disorders
- Electrospun Nanofibers in Biomedical Applications
- Additive Manufacturing and 3D Printing Technologies
- 3D Printing in Biomedical Research
- Clinical Nutrition and Gastroenterology
- Congenital Diaphragmatic Hernia Studies
- Microfluidic and Bio-sensing Technologies
- Mesenchymal stem cell research
- Nanofabrication and Lithography Techniques
- Bone Tissue Engineering Materials
- Prosthetics and Rehabilitation Robotics
Città della Speranza Foundation
2019-2025
UK Dementia Research Institute
2024
King's College London
2024
The Francis Crick Institute
2024
University of Padua
2020-2022
Surgical repair of large muscular defects requires the use autologous graft transfer or prosthetic material. Naturally derived matrices are biocompatible materials obtained by tissue decellularization and commonly used in clinical practice. Despite promising applications described literature, acellular to has been only partially successful, highlighting need for more efficient constructs. Scaffold recellularization means engineering may improve not structure matrix, but also its ability...
Hydrogels are biomaterials that, thanks to their unique hydrophilic and biomimetic characteristics, used support cell growth attachment promote tissue regeneration. The use of decellularized extracellular matrix (dECM) from different tissues or organs significantly demonstrated be far superior other types hydrogel since it recapitulates the native tissue’s ECM composition bioactivity. Different muscle injuries malformations require application patches fillers replenish defect boost Herein,...
Abstract Skeletal muscle (SkM) tissue engineering aims to generate in vitro 3D products that can be implanted patients replace or repair damaged muscles. Having a humanized model able mimic the interaction between innervated recipient and engineered SkMs at functional level would greatly help evaluation of graft potential. Here, is developed allows investigation function, stability, adaptability human neuromuscular (NM) system response an SkM construct. To achieve this, decellularized...
Cell culture devices, such as microwells and microfluidic chips, are designed to increase the complexity of cell-based models while retaining control over conditions have become indispensable platforms for biological systems modelling. From microtopography, microwells, plating larger constructs live imaging chamber slides, a wide variety devices with different geometries in biology laboratories. However, their application projects is increasing exponentially, due combination techniques,...
The production of skeletal muscle constructs useful for replacing large defects in vivo, such as congenital diaphragmatic hernia (CDH), is still considered a challenge. standard application prosthetic material presents major limitations, recurrences remarkable number CDH patients. With this work, we developed tissue engineering approach based on decellularized and human cells the vitro generation diaphragmatic-like tissues proof-of-concept new option surgical treatment diaphragm defects. A...
Abstract Cell culture devices, such as microwells and microfluidic chips, are designed to increase the complexity of cell-based models whilst retaining control over conditions have become indispensable platforms for biological systems modelling. From microtopography, microwells, plating devices larger constructs specific applications live imaging chamber slides, a wide variety with different geometries in biology laboratories. However, while their application projects is increasing...
Abstract Skeletal muscle (SkM) tissue engineering aims to generate in vitro three-dimensional (3D) products that can be implanted patients replace or repair damaged muscles. Having a humanized model able mimic the interaction between innervated recipient and engineered SkMs at functional level would greatly help evaluation of graft potential. Here we developed 3D allowed investigate function, stability, adaptability human NM system response an SkM construct. To achieved this, used...