A5008049320- Cytokine Signaling Pathways and Interactions
- DNA Repair Mechanisms
- Gut microbiota and health
- interferon and immune responses
- Animal Nutrition and Physiology
- CAR-T cell therapy research
- Monoclonal and Polyclonal Antibodies Research
- CRISPR and Genetic Engineering
- Viral Infectious Diseases and Gene Expression in Insects
- Genetic and phenotypic traits in livestock
- Genomics and Chromatin Dynamics
- DNA and Nucleic Acid Chemistry
- Epigenetics and DNA Methylation
- Biochemical Analysis and Sensing Techniques
- Regulation of Appetite and Obesity
- Genomic variations and chromosomal abnormalities
- Reproductive Biology and Fertility
- Multiple Myeloma Research and Treatments
- Agricultural Systems and Practices
- Ruminant Nutrition and Digestive Physiology
- Synthesis and Biological Evaluation
- Plant Genetic and Mutation Studies
- RNA and protein synthesis mechanisms
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
ZheJiang Academy of Agricultural Sciences
2023-2025
Ministry of Agriculture and Rural Affairs
2023-2025
Sichuan University
2023-2025
Zhejiang A & F University
2023-2024
Animal Science Research Institute
2024
Centre National de la Recherche Scientifique
2005-2007
Institut Curie
2007
École Normale Supérieure Paris-Saclay
2005
The gut microbiota exerts a critical influence on energy metabolism homeostasis and productive performance in avian species. Given the diminishing availability of arable land intensifying competition for finite resources between livestock production human populations, agricultural sector faces dual imperatives to enhance efficiency while mitigating ecological footprints. Within this paradigm, optimizing nutrient assimilation commercial waterfowl operations emerges as strategic priority. This...
Bloom's syndrome (BS) is an autosomal recessive human disorder characterized by genomic instability and a predisposition to wide variety of cancers. The gene mutated in BS, BLM, encodes protein containing three domains: N-terminal domain whose function remains elusive, helicase seven 'signature' motifs conserved range helicases C-terminal extension that can be further divided into two sub-domains: RecQ-Ct HRDC. appears essential because point-mutations altering highly cysteine residues...
The egg-laying performance of Shan Ma ducks (Anas Platyrhynchos) is a crucial economic trait. Nevertheless, limited research has been conducted on the this species. We examined routine blood indicators and observed higher levels metabolic immune-related factors in high-egg-production group compared with low-egg-production group. Furthermore, we explored ovarian transcriptome both high- groups using Illumina NovaSeq 6000 sequencing. A total 1357 differentially expressed genes (DEGs) were...
Bloom syndrome (BS) is an autosomal recessive disorder characterized by genomic instability and the early development of many types cancer. Missense mutations have been identified in BLM gene (encoding a RecQ helicase) affected individuals, but molecular mechanism structural basis effects these remain to be elucidated. We analysed five disease-causing missense that are localized helicase core region: Q672R, I841T, C878R, G891E C901Y. The mutants had low ATPase activities their ATP binding...
Antiproliferative, antiviral, and immunomodulatory activities of endogenous type I IFNs (IFN1) prompt the design recombinant IFN1 for therapeutic purposes. However, most designed exhibited suboptimal efficacies against solid tumors. Here, we report evaluation
Bloom syndrome (BS) is a rare human autosomal recessive disorder characterized by marked genetic instability associated with greatly increased predisposition to wide range of cancers affecting the general population. BS arises through mutations in both copies BLM gene which encodes 3'-5' DNA helicase identified as member RecQ family. Several studies support major role for cellular response damage and stalled replication forks. However, specific function(s) remain(s) unclear. The protein...
Introduction This study was conducted to assess the effects of dietary supplementation coated sodium butyrate (CSB) on growth performance, serum antioxidant, immune and intestinal microbiota laying ducks. Methods A total 120 48-week-old ducks were randomly divided into 2 treatment groups: control group (group C fed a basal diet) CSB-treated CSB diet + 250 g/t CSB). Each consisted 6 replicates, with 10 per replicate, trial for 60 days. Results Compared C, showed significant increase in rate...
Residual feed intake (RFI) is a crucial parameter for assessing the feeding efficiency of poultry. Minimizing RFI can enhance utilization and reduce costs. In this study, 315 healthy female ducks were individually housed in cages. Growth performance was monitored during high laying period, from 290 to 325 d age. The cecal transcriptome microbiome 12 with low residual (LRFI) analyzed. Regarding growth performance, LRFI group exhibited significantly lower RFI, conversion ratio (FCR), (Fi)...
ABSTRACT As the global population continues to grow exponentially, competition for resources between livestock and humans has become increasingly intense. Breeding efficient animal breeds, fully utilizing feed resources, reducing environmental damage are major challenges facing industry. To address these issues, enhancing utilization efficiency in poultry industry is crucial. Recent studies have elucidated pivotal role of gut microbiota modulating feeding behavior their host organisms. Thus,...
<p>Supplementary methods, tables, figures and legends to Supplementary Figure 1. The structure of AB loops for sIFN-I IFNα-2b comparison on the sequences IFNα-21. 2. Quantification phosphorylaiton STAT1/3 in 3C 3. Analysis cell surface IFNAR1 levels A549-IFNAR1-KO clones by FACS. 4. shows potent anti-solid tumor effect immunocompromised mice models. 5. treatment decreases proliferation induces senescence vivo. 6. antitumor immunocompetent 7. FACS analysis splenocytes from tumor-bearing...
<div>Abstract<p><b>Purpose:</b> Antiproliferative, antiviral, and immunomodulatory activities of endogenous type I IFNs (IFN1) prompt the design recombinant IFN1 for therapeutic purposes. However, most designed exhibited suboptimal efficacies against solid tumors. Here, we report evaluation <i>in vitro</i> vivo</i> antitumorigenic a novel IFN termed sIFN-I.</p><p><b>Experimental Design:</b> We compared primary tertiary...
<div>Abstract<p><b>Purpose:</b> Antiproliferative, antiviral, and immunomodulatory activities of endogenous type I IFNs (IFN1) prompt the design recombinant IFN1 for therapeutic purposes. However, most designed exhibited suboptimal efficacies against solid tumors. Here, we report evaluation <i>in vitro</i> vivo</i> antitumorigenic a novel IFN termed sIFN-I.</p><p><b>Experimental Design:</b> We compared primary tertiary...
<p>Supplementary methods, tables, figures and legends to Supplementary Figure 1. The structure of AB loops for sIFN-I IFNα-2b comparison on the sequences IFNα-21. 2. Quantification phosphorylaiton STAT1/3 in 3C 3. Analysis cell surface IFNAR1 levels A549-IFNAR1-KO clones by FACS. 4. shows potent anti-solid tumor effect immunocompromised mice models. 5. treatment decreases proliferation induces senescence vivo. 6. antitumor immunocompetent 7. FACS analysis splenocytes from tumor-bearing...
Multiple myeloma (MM) is a malignant plasma cell disease that causes large number of deaths every year. In the present study, we investigated effect bortezomib, first-line drug for MM, on B maturation antigen (BCMA) MM cells in order to obtain better efficacy CAR-T therapy. Flow cytometry and ELISA analysis revealed bortezomib steadily increased BCMA expression level line Nalm6-BCMA, thereby enhancing killing efficiency cells, while increase was sustained, allowing more time effect....
Feed costs account for approximately 60 to 70% of the cost poultry farming, and feed utilization is closely related profitability industry. To understand causes differences in feeding Shan Partridge ducks, we compared hypothalamus transcriptome profiles 2 groups ducks using RNA-seq. The were: 1) low-residual intake (LRFI) group with low but high efficiency, 2) high-residual (HRFI) efficiency. We found 78 DEGs were enriched 9 differential Kyoto Encyclopedia Genes Genome (KEGG) pathways,...