A5033891933- Neuroendocrine Tumor Research Advances
- Lung Cancer Research Studies
- Urinary Tract Infections Management
- Bladder and Urothelial Cancer Treatments
- Peptidase Inhibition and Analysis
- Gyrotron and Vacuum Electronics Research
- S100 Proteins and Annexins
- Cancer-related Molecular Pathways
- IL-33, ST2, and ILC Pathways
- Clusterin in disease pathology
- Ferroptosis and cancer prognosis
- Thyroid Cancer Diagnosis and Treatment
- Reproductive System and Pregnancy
- Cancer, Lipids, and Metabolism
- Antibiotic Resistance in Bacteria
- Cancer, Hypoxia, and Metabolism
- Prostate Cancer Diagnosis and Treatment
- Urinary Bladder and Prostate Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Nephrotoxicity and Medicinal Plants
- Radiopharmaceutical Chemistry and Applications
- Endometriosis Research and Treatment
- Multiple and Secondary Primary Cancers
National Cancer Institute
2024-2025
National Institutes of Health
2024-2025
Center for Cancer Research
2024
Thyroid hormone receptors (TRs) mediate the genomic actions of thyroid hormone. Mutations THRA gene cause a human disease known as resistance to (RTHα). We created mouse model expressing dominant negative mutated TRα1 (Thra1PV/+ mice) that exhibits growth retardation, bone abnormalities, constipation, and anemia, found in RTHα patients. In addition, female Thra1PV/+ mice exhibit decreased fertility. present study, we aimed characterize molecular events leading infertility. Histologically,...
Overexpression of somatostatin receptors (SSTR), particularly SSTR2, is found in gastroenteropancreatic neuroendocrine tumors (GEP-NET), and subsets other solid such as small-cell lung cancer (SCLC). SCLC accounts for approximately 13% to 15% lacks effective therapeutic options. IHC analysis indicates that up 50% are SSTR2-positive, with a substantial subset showing high homogenous expression. Peptide receptor radionuclide therapy radiolabeled analogue, Lu-177 DOTATATE, has been approved...
Anaplastic thyroid cancer (ATC) is the most aggressive cancer, with very limited treatment options. Mutations of p53 are associated lethal outcomes ATC. In this study, we tested hypothesis that wild type (WTp53) mitigates its progression. We used human 8505C cells (from ATC tumors) as a model, harboring BRAF
Anaplastic thyroid cancer (ATC) is a lethal endocrine malignancy. It has been shown that tumor-associated macrophages (TAMs) contribute to the aggressiveness of ATC. However, stimulatory factors could facilitate induction and infiltration TAMs in ATC tumor microenvironment (TME) are not fully elucidated. In this study, we used human leukemia monocytic cell line (THP-1) study differentiation THP-1 into M2-like (M2) by conditioned media (CM) derived from each three cells: 8505C, THJ-11T (11T),...
<p>Tables S1-S4; Figures S1-S3</p>
<div>Abstract<p>Overexpression of somatostatin receptors (SSTR), particularly SSTR2, is found in gastroenteropancreatic neuroendocrine tumors (GEP-NET), and subsets other solid such as small-cell lung cancer (SCLC). SCLC accounts for approximately 13% to 15% lacks effective therapeutic options. IHC analysis indicates that up 50% are SSTR2-positive, with a substantial subset showing high homogenous expression. Peptide receptor radionuclide therapy radiolabeled analogue, Lu-177...
<div>Abstract<p>Overexpression of somatostatin receptors (SSTR), particularly SSTR2, is found in gastroenteropancreatic neuroendocrine tumors (GEP-NET), and subsets other solid such as small-cell lung cancer (SCLC). SCLC accounts for approximately 13% to 15% lacks effective therapeutic options. IHC analysis indicates that up 50% are SSTR2-positive, with a substantial subset showing high homogenous expression. Peptide receptor radionuclide therapy radiolabeled analogue, Lu-177...
<p>Tables S1-S4; Figures S1-S3</p>