Background —Inflammatory reactions in coronary plaques play an important role the pathogenesis of acute atherothrombotic events; inflammation elsewhere is also associated with both atherogenesis generally and its thrombotic complications. Recent studies indicate that systemic markers can identify subjects at high risk events. Methods Results —We used a sensitive immunoradiometric assay to examine association serum C-reactive protein (CRP) incidence first major heart disease (CHD) event 936...

Abstract Background: Increased values of C-reactive protein (CRP), the classical acute phase protein, within range below 5 mg/L, previously considered to be reference interval, are strongly associated with increased risk atherothrombotic events, and clinically significant in osteoarthritis neonatal infection. Methods: A robust new polyclonal-monoclonal solid- IRMA for CRP was developed, a 0.05–10.0 mg/L. Results: Plasma general adult populations from Augsburg, Germany (2291 males 2203...

Plasma viscosity is determined by various macromolecules, eg, fibrinogen, immunoglobulins, and lipoproteins. It may therefore reflect several aspects involved in cardiovascular diseases, including the effects of classic risk factors, hemostatic disturbances, inflammation. We examined association plasma with incidence a first major coronary heart disease event (CHD; fatal nonfatal myocardial infarction cardiac death; n=50) 933 men aged 45 to 64 years MONICA project Augsburg, Germany. The rate...

S ummary . A study has been made of 420 bone marrow biopsies from patients with multiple myeloma (220), idiopathic monoclonal gammapathy (50), reactive plasmacytosis (42) and solitary plasmacytoma (22). Histology immunohistological parameters were more reliable than cytology in distinguishing a neoplastic plasmacytosis. Histological variables correlated the clinical features to determine factors which value predicting prognosis. Plasma cell maturity extent infiltration biopsy by cells proved...

Recent studies have suggested that several hemostatic factors, leukocyte count, and plasma viscosity are predictive of coronary heart disease. Detailed analyses on lifestyle correlates, in particular lipids lipoproteins, determinants blood rheology not been reported from epidemiological studies.We studied the relation between components lipoproteins a large sample population aged 25-64 years. The rheological parameters investigated were viscosity, hemoglobin, total serum protein; lipoprotein...

The incidence of cardiovascular diseases is increased in winter months. Recent studies have shown seasonal changes plasma viscosity, fibrinogen, and factor VII activity with elevated levels during winter. An increase these factors generates a "hypercoagulable state," which may lead to rise morbidity mortality. It has been suggested that an upper respiratory infections might be the underlying cause for raised acute-phase reactants, particular season. We investigated variations 26 parameters,...

Regular leisure-time physical activity (LTPA) is inversely associated with coronary heart disease (CHD). This has been mainly explained by its impact on traditional CHD risk factors, but more recently it was also shown to lower fibrinogen, which largely determines plasma viscosity. No data the effect of work (WA) viscosity have published.We studied relationship between self-reported LTPA or WA and as well other factors in 3522 men women age 25 64 years. Physical assessed questionnaire. both...

Bone marrow biopsies of 850 patients with chronic myeloproliferative disorders were taken at initial diagnosis; and 169 sequential over periods one to 188 months. Three micron sections all evaluated semiquantitatively reference the proliferating cell lines, anomalies megakaryocytes, fibrosis or osteosclerosis. Correlations between histological findings, clinical, haematological, survival data analysed statistically. The predominant lines distinguished classical entities polycythaemia vera,...

Bone marrow biopsy specimens taken on initial investigation of 134 patients with hairy cell leukemia (HCL) were processed into plastic, and sections cut at 3 μm used for histologic histomorphometric evaluation. Twenty-four clinical, 10 histologic, four variables tested their prognostic significance. involvement was found in all cases, the basis morphology, cells divided three types: ovoid (47%), convoluted (37%), indented (16%); this classification proved to be highly significant test...

The relationship between determinants of blood viscosity and pressure (BP) variables was studied in a large sample population aged 25 to 64 years. Plasma viscosity, hemoglobin, total serum protein were examined. Systolic diastolic BP the prevalence hypertension showed crude positive association with plasma levels both sexes. Age, body mass index, appeared have confounding effect on this relationship, whereas smoking behavior, alcohol consumption did not. A also found men women; however,...

S ummary . Bone marrow biopsies of 678 untreated patients with established malignant non‐Hodgkin's lymphomas (ML) were investigated. The bone was involved in 468 cases, an overall frequency 69%. Kiel classification the ML (based on lymph node histology) applied and classified: lymphocytic 36%, ‘hairy cell’24%, lymphoplasmacytic/cytoid 24%, centrocytic 6%, centroblastic/centrocytic 4%, lymphoblastic (without ALL) 3%, centroblastic 2% immunoblastic 1%. life tables similar whether classified...

Several studies have reported on an increased incidence of cardiovascular events during winter months (1). Some authors (2) suggested that acute-phase response triggered by upper respiratory tract infections is responsible for the higher acute coronary syndromes months. Serum concentrations C-reactive protein (CRP), major reactant, been consistently associated with endpoints (3)(4)(5). Because its short plasma half-life 19 h, CRP synthesis rate only significant determinant concentration and...

The prognostic value of the Rai clinical staging system and a series bone marrow features was examined in 167 untreated patients with CLL. fell into three groups: those limited disease, stages 0 I, median survival 107 months; intermediate stage II, 44 extensive III IV, 27 months. Two types infiltration patterns, diffuse nodular, were found marrow, these associated significantly different times: 34 115 months respectively. It is suggested that nodular patterns relate to rapidity progress...

Several studies have reported a strong association between various markers of the acute‐phase response and death from cardiovascular diseases all‐cause mortality. Inflammation at low level intensity may be common phenomenon associated with majority causes owing to chronic diseases. We sought investigate plasma viscosity mortality in cohort apparently healthy men. The study population consisted 964 men aged 45–64 years entry, randomly selected general taking part first MONICA–Augsburg survey...

The neurohumoral responses after 10 mg of felodipine extended release (ER), a new dihydropyridine calcium antagonist, and 25 hydrochlorothiazide (HCTZ) were compared in randomized, double-blind, crossover trial 28 mild to moderate hypertensives. Antihypertensive drugs gradually discontinued. Felodipine ER, was given once daily for 2 weeks; another washout period 1 week, patients switched HCTZ vice versa. Blood pressure (BP) measured at baseline, 2.5 h medication, weeks treatment (24...

Data from several epidemiologic studies have suggested that, among other variables, hematocrit and fibrinogen may constitute risk factors for high blood pressure. As part of a population survey cardiovascular factors, plasma viscosity hemoglobin were measured. Blood pressure was determined under standardized conditions according to the recommendations AHA. A two- stage age-sex-stratified cluster sample 5,312 persons, aged twenty-five sixty-four years, selected mixed urban/rural target...

The haemorheological effects of felodipine extended release (ER), a new dihydropyridine calcium antagonist, were compared with hydrochlorothiazide (HCTZ) in 28 mild to moderate hypertensives (18 men and 10 women, aged 30-70 years) randomized, double-blind, crossover trial. Antihypertensive drugs gradually discontinued. Felodipine Er, mg, was given once daily for 2 weeks, after another wash-out period 1 week, patients switched 25 mg HCTZ, daily, vice versa. Whole blood viscosity (BV) at three...

Abstract Purpose The aim of the present study was to determine incidence, patient characteristics, and risk factors for severe, contact lens‐related keratitis in patients need hospitalization. Methods Keratitis defined as severe when disease required All with hospitalized at our department between 1 January 2018 31 December 2020 were interviewed a questionnaire, about their use lenses knowledge complications. Clinical information collected from medical records. Results A total 41 (42 eyes)...