A5090912940- Endoplasmic Reticulum Stress and Disease
- Cardiovascular Health and Disease Prevention
- Cardiovascular Function and Risk Factors
- Lymphatic System and Diseases
- Lymphatic Disorders and Treatments
Normandie Université
2023
Inserm
2023
Université de Rouen Normandie
2023
Cardiac lymphatics have emerged as potential targets in cardiovascular diseases (CVDs). However, we recently reported that despite extensive lymphatic expansion during experimental cardiac pressure-overload, drainage remained insufficient. To unravel the cellular and molecular mechanisms underlying dysfunction CVDs, applied single-cell (sc) analyses a murine heart failure model. Transaortic constriction (TAC), C57BL/6J BALB/c mice, was used to model chronic pressure-overload-induced...
Abstract Blocking inflammatory pathways, such as the inflammasome or IL-1β, is a promising therapeutic target in both ischemic and non-ischemic heart failure (HF). We hypothesize that IL-1β may stimulate cardiac lymphangiogenesis, driven by left ventricular dilation HF. Thus, blocking signaling reduce which could delay resolution of myocardial edema inflammation, aggravate fibrosis, accelerate HF development. Here, we investigated effects early versus late anti-IL-1β treatment during...