A5074776852- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Bladder and Urothelial Cancer Treatments
- Pancreatitis Pathology and Treatment
- Neuroendocrine Tumor Research Advances
- Renal cell carcinoma treatment
- Renal and related cancers
- Molecular Biology Techniques and Applications
- Urinary and Genital Oncology Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Colorectal and Anal Carcinomas
- Cervical Cancer and HPV Research
- Breast Cancer Treatment Studies
- HER2/EGFR in Cancer Research
- Ear and Head Tumors
- Chronic Lymphocytic Leukemia Research
- Gene expression and cancer classification
- Lung Cancer Treatments and Mutations
- Cancer Treatment and Pharmacology
- Breast Lesions and Carcinomas
- Immunotherapy and Immune Responses
- Oral and Maxillofacial Pathology
- Urologic and reproductive health conditions
University of Massachusetts Chan Medical School
2014-2024
Baystate Health
2024
UMass Memorial Medical Center
2012-2021
Memorial Medical Center
2011-2020
MelroseWakefield Healthcare
2019
Massachusetts General Hospital
2014-2019
Virginia Commonwealth University
2014
Mount Sinai Hospital
2014
University of Vermont
2014
Scope
2014
Pulmonary Langerhans cell histiocytosis (PLCH) is an idiopathic cigarette smoking-related disorder of the lung. Molecular changes in cellular or fibrotic stages PLCH have not been investigated. We studied prevalence extracellular signal-regulated kinase (ERK) pathway mutations different and other non-PLCH lung diseases.The cohort included 28 with (n = 10), mixed cellular/fibrotic 4) histology 14). Seven cases had concurrent multi-focal/multi-lobar tumours. Respiratory bronchiolitis...
To evaluate insulin-like growth factor-II mRNA binding protein 3 (IMP3), which is an oncofetal RNA-binding expressed in pancreatic carcinomas and detectable by immunohistochemistry, diagnosis of cancer.We retrospectively identified 25 consecutive endoscopic ultrasound-guided fine needle aspiration biopsies with available cell blocks, including 12 invasive ductal 13 cases chronic pancreatitis. Immunostains were performed on 4-microm tissue sections using standard techniques. Cytoplasmic...
Minimally invasive sampling by cytology or core needle biopsy often provides an initial diagnosis for treatment in patients with lung nodules. From these limited specimens, multiple molecular studies are frequently requested. Current guidelines from the US Food and Drug Administration recommend using formalin-fixed paraffin-embedded tissue sections detection of anaplastic lymphoma kinase (ALK) gene rearrangement fluorescence situ hybridization (FISH). The authors compared alcohol-fixed...
OBJECTIVES To assess the early histological effects of pharmacological androgen deprivation (AD), which have been assessed only over longer periods, as surgical castration leads rapidly to diminished cell proliferation and enhanced death within prostate. PATIENTS AND METHODS With Institutional Review Board approval, 35 patients were randomly assigned (seven in each group) receive 0, 7, 14, 21 28 days AD (flutamide, 250 mg orally three times/day, one injection with leuprolide acetate 7.5 mg)...
Sensitive and specific assays for human papillomavirus (HPV) are essential patient management. In this study, we directly compared the efficacy of Hybrid Capture 2 (HC2; Qiagen, Valencia, CA) Cervista (Hologic, Madison, WI). Consecutive cervical cytology specimens (n = 601) were tested using HC2, HR, HPV 16/18 with analysis only cytology-negative cases 533). Results indicated no significant difference (P .458) in prevalence rates between HC2 (7.5%) HR (8.5%). The was 1.6%. negative...
Mesenteric Lymph Node Cavitation in Celiac DiseaseDenise Reddy, Caryl Salomon, Terrence C. Demos and Ediz CosarAudio Available | Share
Primary melanocytic neoplasms of the central nervous system ( CNS ) are uncommon and must be distinguished from metastatic lesions as patients with disease carry a worse prognosis. Therefore, tools to aid in diagnosis primary neoplasm would clinical utility. neoplasms, including uveal melanomas have frequent mutations GNAQ GNA11 , but rare cutaneous mucosal melanomas. Additionally, often exhibit monosomy 3 conferring an elevated risk metastasis. We present 63 year‐old male thoracic spinal...
// Ali Sakhdari 1 , 5 Parnian Ahmadi Moghaddam 4 6 Chi Young Ok Otto Walter Keith Tomaszewicz Mandi-Lee Caporelli Xiuling Meng Jennifer LaFemina 2 Giles Whalen Edward Belkin 3 Jaroslav Zivny Wahid Wassef Bruce A. Woda Lloyd M. Hutchinson and Ediz F. Cosar University of Massachusetts Medical School, Department Pathology, Worcester, MA, USA Surgery, Medicine, General Hospital, Boston, MD Anderson Cancer Center, Hematopathology, Houston, TX, Texas, Health Science Correspondence to: Hutchinson,...
Context.—UroVysion fluorescent in situ hybridization (FISH) is routinely used to detect urothelial carcinoma (UC). A positive threshold defined as chromosome polysomy 4 or more cells, which also includes tetrasomy, a natural product of cell division. Objectives.—To evaluate tetrasomy for UC detection and explore the relation surgical diagnosis patient history. Design.—The FISH was performed on 1532 urine samples from patients with cytology results years follow-up. We created separate...
Urine cytology can reliably diagnose high-grade urothelial carcinoma (HGUC) but not low-grade (LGUC), and a more sensitive test is needed. Previously, pilot study highlighted the possible diagnostic utility of next-generation sequencing (NGS) in identifying both LGUC HGUC urine specimens.Twenty-eight ThinPrep specimens preceding or subsequent bladder tumor biopsy/resection obtained within 3 months were included (LGUC, n = 15; HGUC, 13). A customized, bladder-specific NGS panel was performed;...
Objectives. The rare urachal adenocarcinoma (UAC) of the bladder has striking morphologic and immunohistochemical overlap with colorectal (CAC) (BAC). To date, mutational status in UAC BAC not been well investigated. Methods. We retrospectively evaluated 34 UACs (mucinous, n = 9; intestinal, 3; signet ring cell, 1; otherwise specified, 21) 4 BACs (n 4). Next-generation sequencing analysis 50 cancer “hotspot” gene mutations using Ampliseq Cancer Hotspot Panel v2 was performed. Two cases did...
We present an 18-year-old man with painless rectal bleeding, hematuria and diffuse cavernous hemangioma of the rectum sigmoid colon. Thirty units blood were transfused during interval preceding definitive surgery. Low anterior resection partial cystectomy performed. During postoperative period no bleeding occurred, but he died massive intracerebral 10 months after operation.
Abstract Objective.—Polymerase chain reaction amplification of DNA for T-cell receptor (TCR) gene rearrangement analysis is helpful in the evaluation lymphoproliferative disorders. Detection polymerase products limited by poor resolution bands analyzed agarose or polyacrylamide gel electrophoresis. To improve detection a clonal population, we used temperature gradient electrophoresis (TGGE) as an alternative method TCR rearrangement. Design.—One hundred eighteen archival samples were...
To the Editor: Intralymphatic histiocytosis (ILH) is a rare benign condition depicted histologically by accumulation of macrophages within dilated lymphatic vessels. It most commonly occurs in patients with rheumatoid arthritis (RA) but has been reported association joint replacement, systemic diseases, and rarely malignancies.1–8 We report an unusual case ILH patient lung adenocarcinoma. A 75-year-old woman medical history hypertension hypercholesterolemia had several month erythematous...