A5049842115- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- MicroRNA in disease regulation
- Neurogenesis and neuroplasticity mechanisms
- Cancer-related molecular mechanisms research
- Colorectal and Anal Carcinomas
- Neuroinflammation and Neurodegeneration Mechanisms
- Global Maternal and Child Health
- RNA modifications and cancer
- Lymphoma Diagnosis and Treatment
- Circular RNAs in diseases
- Maternal and Perinatal Health Interventions
- Cancer-related gene regulation
- interferon and immune responses
- Gestational Diabetes Research and Management
- Neonatal Respiratory Health Research
- Health disparities and outcomes
- Pluripotent Stem Cells Research
- Anesthesia and Neurotoxicity Research
- Protein Degradation and Inhibitors
- Pancreatic and Hepatic Oncology Research
- Congenital Diaphragmatic Hernia Studies
- Genetic factors in colorectal cancer
- Traditional Chinese Medicine Analysis
- Gastrointestinal Tumor Research and Treatment
Second People’s Hospital of Huai’an
2017-2025
Xuzhou Medical College
2018-2025
Yangzhou University
2024-2025
UMass Memorial Health Care
2021-2025
Beijing Tian Tan Hospital
2024
Capital Medical University
2024
The First People's Hospital of Changzhou
2019-2024
University of Massachusetts Chan Medical School
2018-2024
Wuhan University
2017-2024
Renmin Hospital of Wuhan University
2024
NG2 glia constitute a fourth major glial cell type in the mammalian central nervous system (CNS) that is distinct from other types. Although circumstantial evidence suggests some differentiate into oligodendrocytes, their vivo fate has not been directly examined. We have used bacterial artificial chromosome (BAC) modification technique to generate transgenic mice express DsRed or Cre specifically NG2-expressing (NG2+) cells. In NG2DsRedBAC mice, was expressed NG2+ cells throughout postnatal...
NG2-expressing glia (NG2 cells, polydendrocytes) appear in the embryonic brain, expand perinatally, and persist widely throughout gray white matter of mature central nervous system. We have previously reported that NG2 cells generate oligodendrocytes both a subset protoplasmic astrocytes ventral forebrain spinal cord. To investigate temporal changes cell fate, we generated NG2creER™BAC transgenic mice, which tamoxifen-inducible Cre is expressed cells. induction at day 16.5, postnatal (P) 2,...
NG2 cells represent a unique glial cell population that is distributed widely throughout the developing and adult CNS distinct from astrocytes, mature oligodendrocytes microglia. The ability of to differentiate into myelinating has been documented in vivo vitro. We reported recently forebrain but subpopulation protoplasmic astrocytes (Zhu et al ., 2008). However, fate spinal cord cerebellum remained unknown. To investigate caudal central nervous system (CNS) regions vivo, we examined...
NG2-expressing cells (NG2 or polydendrocytes) generate oligodendrocytes throughout the CNS and a subpopulation of protoplasmic astrocytes in gray matter ventral forebrain. The mechanisms that regulate their oligodendrocyte astrocyte fate degree to which they exhibit lineage plasticity vivo have remained unclear. basic helix-loop-helix transcription factor Olig2 is required for specification differentiation. We found expression spontaneously downregulated NG2 normal embryonic forebrain as...
CBP and EP300 are highly homologous, bromodomain-containing transcription coactivators involved in numerous cellular pathways relevant to oncology. As part of our effort explore the potential therapeutic implications selectively targeting bromodomains, we set out identify a CBP/EP300 bromodomain inhibitor that was potent both vitro target engagement assays selective over other members family. Reported here is series cell-potent probes derived from fragment screening hit...
NG2 cells, also referred to as oligodendrocyte precursor cells (OPCs) or polydendrocytes, represent a major resident glial cell population that is distinct from mature astrocytes, oligodendrocytes, microglia, and neural stem exist throughout the gray white matter of developing central nervous system (CNS). While their most established fate oligodendrocyte, they retain lineage plasticity in an age- region-specific manner. During development, contribute 36% protoplasmic astrocytes ventral...
GSK-3 is an essential mediator of several signaling pathways that regulate cortical development. We therefore created conditional mouse mutants lacking both GSK-3α and GSK-3β in newly born excitatory neurons. Gsk3-deleted neurons expressing upper layer markers exhibited striking migration failure all areas the cortex. Radial hippocampus was similarly affected. In contrast, tangential not grossly impaired after Gsk3 deletion interneuron precursors. extended axons developed dendritic arbors....
Abstract NG2 cells express the chondroitin sulfate proteoglycan and are a fourth type of glia distinct from astrocytes, oligodendrocytes, microglia. generate oligodendrocytes but have also been reported to represent neuronal progenitor in postnatal mouse subventricular zone (SVZ). We performed detailed immunohistochemical analysis SVZ, rostral migratory stream (RMS), olfactory bulb granule cell layer (OB GCL), which constitute neurogenic niche forebrain. SVZ RMS expressed oligodendrocyte...
Abstract Oral squamous cell carcinoma (OSCC) is the most common malignant tumor of head and neck region. Circular RNA (circRNA), as one kind noncoding RNA, involves in biological processes diverse cancers. circRNA functions mainly microRNA (miRNA) sponge, competitively binding to miRNAs regulate target gene expressions. However, expression profiles roles circRNAs OSCC are still unexplored. microarrays quantitative real‐time polymerase chain reaction was used identify hsa_circRNA_100533...
Ewing sarcoma (EwS) is an aggressive tumor that affects children and young adults. Patients with relapsed/refractory diseases have limited treatment options. Targeting the driver fusion oncoproteins of EwS remains a technical problem. Epigenetic mechanisms been pointed out as key players alternative therapeutic targets in EwS. Here, we reported lysine demethylase 5B (KDM5B), histone specifically demethylates tri- di-methylated H3 Lys-4 (H3K4), was upregulated overexpressed KDM5B correlated...
The prevalence of high-risk pregnancy increased after the implementation two-child policy in China, but impact this change on burden and profile multiple factors (MHFP) has been insufficiently explored. We hypothesised that MHFP might have changed was implemented aimed to estimate prevalence, intercorrelation, outcomes before its introduction.
Chemokines are a family of small cytokines, which signalling proteins secreted by cells. The principal role chemokines is to serve as chemoattractants guide the migration their target Chemokine C-X3-C motif ligand 1 (CX3CL1) protein-coding gene fractalkine, serves for chemokine receptor (CX3CR1) and integrins. However, roles CX3CL1 in different pathological types lung cancer remain poorly understood. present study aimed investigate potential clinical biological function mRNA expression...
Abstract Background Passive-active immunoprophylaxis against mother-to-child transmission (MTCT) of hepatitis B virus (HBV) recommends administering immunoglobulin (HBIG) and birth-dose vaccine in infants within 12 or 24 hours after birth. With this protocol, MTCT HBV still occurs 5–10% HBV-infected mothers with positive e antigen (HBeAg). The present study aimed to investigate whether earlier administration HBIG birth can further increase protection efficacy. Methods We conducted a...
The biological function of bromodomains, epigenetic readers acetylated lysine residues, remains largely unknown. Herein we report our efforts to discover a potent and selective inhibitor the bromodomain cat eye syndrome chromosome region candidate 2 (CECR2). Screening internal medicinal chemistry collection led identification pyrrolopyridone chemical lead, subsequent structure-based drug design CECR2 (GNE-886) suitable for use as an in vitro tool compound.
Long non-coding RNA (lncRNA), which is greater than 200 nucleotides, a class of molecules without protein coding function. In recent years, studies have shown that lncRNAs are associated with cancers. They affecting the occurrence and development However, diagnostic significances in gastric cancer largely unknown. this study, we focused on AI364715, one typical lncRNA. A total 186 samples were collected from two centers. To find potential association between its level cancer, first 75 paired...
Objective: This survey followed the birth population-based study conducted in 2010 Huai'an, Jiangsu Province, with aim to estimate perinatal-neonatal mortality and preterm rate emerging regions similar maternal-fetal neonatal care conditions China.Materials methods: Data of total births 2015 were prospectively collected by regional perinatal network collaboration a subprovincial region population 5,644,500 gross domestic production 9082 USD per capita.Results: The 59,424 registries...
In the present study, expression of microRNA (miR)‑671‑3p in non‑small‑cell lung cancer (NSCLC) was detected via reverse transcription‑quantitative polymerase chain reaction analysis, and its role cell proliferation, apoptosis, migration invasion investigated Cell Counting Kit‑8, colony formation, flow cytometry, Transwell scratch assays, respectively. It observed that miR‑671‑3p upregulated NSCLC tissues lines (A549 H1975). Treatment with inhibitors suppressed invasion, increased apoptosis...