A5100433688- Phagocytosis and Immune Regulation
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Microbial Inactivation Methods
- Target Tracking and Data Fusion in Sensor Networks
- Cancer-related molecular mechanisms research
- Autophagy in Disease and Therapy
- HVDC Systems and Fault Protection
- Space Satellite Systems and Control
- Immune cells in cancer
- Multilevel Inverters and Converters
- Neonatal Health and Biochemistry
- Liver Disease Diagnosis and Treatment
- Inertial Sensor and Navigation
- Immune Cell Function and Interaction
- Liver Disease and Transplantation
- Cancer Genomics and Diagnostics
- Microgrid Control and Optimization
Sun Yat-sen University
2019-2023
Sun Yat-sen University Cancer Center
2022
The Seventh Affiliated Hospital of Sun Yat-sen University
2021
Eighth Affiliated Hospital of Sun Yat-sen University
2020
Tumor-associated macrophages (TAM) are primarily of the M2 type that facilitates tumor growth, metastasis, and immunosuppression. Therefore, repolarizing TAMs to pro-inflammatory M1 is a promising therapeutic strategy against cancer. Toll-like receptor (TLR) agonists like CpG oligodeoxynucleotides (CpG ODNs) can induce anti-tumor macrophages, however, their applications in vivo limited by lack effective delivery approaches. Naked ODNs fail penetrate cell membranes easily cleared nucleases,...
Irreversible electroporation (IRE) is an effective method for treating pancreatic ductal adenocarcinoma (PDAC). It remains unclear whether IRE can induce a specific immune response by stimulating macrophages. Here, the associated markers of macrophages were analyzed after exposure to tumor culture supernatant (TSN) cells treated with electroporation. Subcutaneous and orthotopic PDAC models also used evaluate effect macrophage polarization induced IRE. Aside from its direct killing effect,...
Irreversible electroporation (IRE) has been demonstrated to be a safe and effective method for locally advanced pancreatic cancer (LAPC). The aim of this study was evaluate the immunomodulatory effect after IRE prognostic value variations immune parameters in LAPC patients IRE. Peripheral blood samples 34 were obtained preoperatively on third day (D3) seventh (D7) IRE, respectively. phenotypes lymphocytes analyzed by flow cytometry, dynamic changes serum levels cytokines, complement,...
Ewing sarcoma (EwS) is an aggressive tumor that affects children and young adults. Patients with relapsed/refractory diseases have limited treatment options. Targeting the driver fusion oncoproteins of EwS remains a technical problem. Epigenetic mechanisms been pointed out as key players alternative therapeutic targets in EwS. Here, we reported lysine demethylase 5B (KDM5B), histone specifically demethylates tri- di-methylated H3 Lys-4 (H3K4), was upregulated overexpressed KDM5B correlated...
Abstract Alternating therapeutic plasma exchange with double molecular adsorption system can rapidly remove bilirubin and ammonia supplement the essential substance from blood, which could be used as an effective treatment for fulminant hepatic failure.
This paper proposes a robust control allocation for the capture of space inertial sensor's test mass under overcritical conditions. Uncertainty factors system condition are analyzed first, and 6-DOF dynamics model with uncertainty is established. Subsequently, time-varying weight function designed to coordinate generalized forces. Moreover, method proposed distribute commanded forces torques into individual electrodes in an optimal manner, which takes account uncertainties. transforms...
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