A5049220626- Ocular Oncology and Treatments
- Cancer-related Molecular Pathways
- Microtubule and mitosis dynamics
- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Nitric Oxide and Endothelin Effects
- Ubiquitin and proteasome pathways
- Cardiovascular Syncope and Autonomic Disorders
- Retinal Development and Disorders
- Bone health and osteoporosis research
- Protease and Inhibitor Mechanisms
- Immunotherapy and Immune Responses
- Cancer, Hypoxia, and Metabolism
- Bioactive natural compounds
- Bone and Joint Diseases
- Wnt/β-catenin signaling in development and cancer
- Sympathectomy and Hyperhidrosis Treatments
- Neuroblastoma Research and Treatments
- Virus-based gene therapy research
- Spinal Fractures and Fixation Techniques
- Hip and Femur Fractures
- Renal function and acid-base balance
- Neurosurgical Procedures and Complications
- Natural product bioactivities and synthesis
Wright State University
2023-2024
Dayton VA Medical Center
2024
Indiana University – Purdue University Indianapolis
2014-2018
Indiana University School of Medicine
2014-2018
Hypertension Institute
2015-2018
Marian University - Indiana
2018
Indiana University
2015
Midwest Eye Institute
2015
Eye diseases characterized by excessive angiogenesis such as wet age-related macular degeneration, proliferative diabetic retinopathy, and retinopathy of prematurity are major causes blindness. Cremastranone is an antiangiogenic, naturally occurring homoisoflavanone with efficacy in retinal choroidal neovascularization models antiproliferative selectivity for endothelial cells over other cell types. We undertook a cell-based structure-activity relationship study to develop more potent...
Abstract Ocular neovascularization underlies major blinding eye diseases such as “wet” age‐related macular degeneration (AMD). Despite the successes of treatments targeting vascular endothelial growth factor (VEGF) pathway, resistant and refractory patient populations necessitate discovery new therapeutic targets. Using a forward chemical genetic approach, we identified heme synthesis enzyme ferrochelatase (FECH) necessary for angiogenesis in vitro vivo . FECH is overexpressed wet AMD eyes...
The mitotic kinesin KIF14 has an essential role in the recruitment of proteins required for final stages cytokinesis. Genomic gain and/or overexpression been documented retinoblastoma and a number other cancers, such as breast, lung ovarian carcinomas, strongly suggesting its oncogene. Despite evidence oncogenic properties vitro xenografts, Kif14's tumor progression not previously studied transgenic cancer model. Using novel Kif14 overexpressing, simian virus 40 large T‐antigen (TAg‐RB)...
Abstract The KIF14 locus is gained and overexpressed in various malignancies, with prognostic relevance. Its protein product, a mitotic kinesin, accelerates growth of normal mammary epithelial cells vitro retinoblastoma tumours mouse model, while knockdown blocks brain, liver, ovarian, breast, prostate, other tumour xenografts. However, the tumour-initiating effects Kif14 overexpression have not been studied. We aged cohort -overexpressing transgenic mice wild-type littermates documented...
Abstract KIF14 is a mitotic kinesin and microtubule-associated molecular motor that plays an essential role in the last stages of cytokinesis. In multiple cancer types, KIF14, overexpression tumors correlates with stage, aggressiveness, poor patient outcomes. There considerable interest as possible oncogene, since locus common region genomic gain cancers. this study, wild type BDF-1 mice strain constitutively overexpressing Kif14, known Kif14-Tg mice, were evaluated at end their natural...