A5102009884- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Advances in Oncology and Radiotherapy
- Global Cancer Incidence and Screening
- CAR-T cell therapy research
- Economic and Financial Impacts of Cancer
- Diversity and Career in Medicine
- Radiopharmaceutical Chemistry and Applications
- Arsenic contamination and mitigation
- Brain Metastases and Treatment
- Cancer, Hypoxia, and Metabolism
- FinTech, Crowdfunding, Digital Finance
- Cancer, Stress, Anesthesia, and Immune Response
- Breast Cancer Treatment Studies
- interferon and immune responses
- Music and Audio Processing
- Microplastics and Plastic Pollution
- Cervical Cancer and HPV Research
- Infective Endocarditis Diagnosis and Management
- Innovations in Medical Education
- Stock Market Forecasting Methods
- Nanoplatforms for cancer theranostics
- Cardiac Structural Anomalies and Repair
- Video Analysis and Summarization
- Mine drainage and remediation techniques
University of Wisconsin–Madison
2020-2023
Vietnam National University, Hanoi
2022-2023
National Economics University
2022
University Medical Center HCMC
2009
Low-dose targeted radionuclide therapy combined with immune checkpoint inhibition enhances complete response rates in preclinical tumor models.
Abstract Radiation therapy (RT) activates an in situ vaccine effect when combined with immune checkpoint blockade (ICB), yet this may be limited because RT does not fully optimize tumor antigen presentation or overcome suppressive mechanisms the tumor-immune microenvironment. To this, we develop a multifunctional nanoparticle composed of polylysine, iron oxide, and CpG (PIC) to increase presentation, ratio M1:M2 tumor-associated macrophages, enhance stimulation type I interferon response...
Clinical interest in combining targeted radionuclide therapies (TRT) with immunotherapies is growing. External beam radiation therapy (EBRT) activates a type 1 interferon (IFN1) response mediated via stimulator of genes (STING), and this critical to its therapeutic interaction immune checkpoint blockade. However, little known about the time course IFN1 activation after EBRT or whether may be induced by decay TRT source.
<h3>Importance</h3> Women outnumber men in US medical school enrollment, but they represent less than 40% of academic oncology faculty. <h3>Objective</h3> To identify the key factors associated with female oncologists' decision to pursue or nonacademic practice and characterize their perceptions about current career. <h3>Design, Setting, Participants</h3> This cross-sectional survey study was distributed through email social media physicians United States. The open for 3 months, from August...
In head and neck squamous cell carcinoma (HNSCC) tumors that over-expresses huEGFR, the anti-EGFR antibody, cetuximab, antagonizes tumor viability sensitizes to radiation therapy. However, immunologic interactions between cetuximab therapy are not well understood. We transduced two syngeneic murine HNSCC lines express human EGFR (MOC1- MOC2-huEGFR) in order facilitate evaluation of cetuximab. Cetuximab was capable inducing antibody-dependent cellular cytotoxicity (ADCC) MOC1- MOC2-huEGFR...
Brain metastases develop in over 60% of advanced melanoma patients and negatively impact quality life prognosis. In a murine model, we previously showed that an situ vaccination (ISV) regimen, combining radiation treatment intratumoral (IT) injection immunocytokine (IC: anti-GD2 antibody fused to IL2), along with the immune checkpoint inhibitor anti-CTLA-4, robustly eliminates peripheral flank tumors but only has modest effects on co-occurring intracranial tumors. this study, investigated...
Background Immune checkpoint inhibition (ICI) alone is not efficacious for a large number of patients with melanoma brain metastases. We previously established an in situ vaccination (ISV) regimen combining radiation and immunocytokine to enhance response ICIs. Here, we tested whether ISV inhibits the development metastases murine model. Methods B78 (GD2 + ) ‘primary’ tumors were engrafted on right flank C57BL/6 mice. After 3–4 weeks, primary treated (radiation (12 Gy, day 1), α-GD2...
Arsenic (As) in rice has been known as a worldwide human health threat that results originally from the accumulation of As soil many cultivation regions. This study aims to evaluate levels soil–rice system Mekong River delta (MRD) with special focuses on geographical distribution and relation physio-chemical properties. It was found contents varied 0.3 15.9 mg kg−1 (x˜ = 7.22 ± kg−1), whereas straw content about one order magnitude lower 0.92 0.1 kg−1). The grain “not detectable” 1115 µg 73...
Sera of immune mice that were previously cured their melanoma through a combined radiation and immunocytokine immunotherapy regimen consisting 12 Gy external beam the intratumoral administration an (anti-GD2 mAb coupled to IL-2) with long-term immunological memory showed strong antibody-binding against tumor cell lines via flow cytometric analysis. Using high-density whole-proteome peptide array (of 6.090.593 unique peptides), we assessed potential protein-targets for antibodies found in...
Surgical resection or hypo-fractionated radiation therapy (RT) in early-stage non-small cell lung cancer (NSCLC) achieves local tumor control, but metastatic relapse remains a challenge. We hypothesized that immunotherapy with anti-CTLA-4 and bempegaldesleukin (BEMPEG; NKTR-214), CD122-preferential IL2 pathway agonist, after primary RT would reduce metastases syngeneic murine NSCLC model. Mice bearing Lewis Lung Carcinoma (LLC) tumors were treated combinations of BEMPEG, anti-CTLA-4,...
In this paper, we present a deep learning based multimodal system for classifying daily life videos. To train the system, propose two-phase training strategy. first phase (Phase I), extract audio and visual (image) data from original video. We then with independent models. After processes, obtain embeddings by extracting feature maps pre-trained second II), fusion layer to combine audio/visual dense classify combined embedding into target scenes. Our extensive experiments, which were...
Abstract: Thе purposе of this study is to sее if Nigеrian mothеrs with grеatеr lеvеls еducation producе hеalthiеr infants (N=64,750). According thе findings, a highеr еducational lеvеl had than lowеr lеvеl. In tеrms statistics, onе additional yеar in Nigеria linkеd 7.0448 gram risе birth wеight and 0.21 pеrcеntagе point rеduction low risk.
Machine Learning (ML) is a well-known term in the technological field. However, using ML models financial institutions matter of concern. In fact, 4.0 Industry has encouraged them to expand their digital system bring best experience for clients. This journal will discuss definition and applications ML, actual situation Vietnam Finetech Market. Thereby, we make predictions about future institutions, which determines use activities.
11040 Background: Although women outnumber men in US medical school enrollment, constitute < 50% of faculty academic oncology. This study aimed to determine factors affecting oncologists’ decisions pursue versus non-academic oncology Hematology/Oncology (HO), Pediatric Oncology (PO), Radiation (RO), and Surgical (SO), characterize the challenges oncologists face. Methods: A survey was designed collect cross-sectional data on career choices among oncologists. The distributed via email...
Abstract Background: Radiation (RT) activates a type 1 interferon (IFN1) response and this is critical to the effect of RT in priming immune checkpoint blockade (ie anti-CTLA4). However, little known about time course effect. Clinical interest utilizing systemically administered targeted radionuclide therapy agents (TRT) growing as these can be used target multiple sites disease including micro-metastases. It unclear how IFN1 activation induced by continuous delivery during exponential decay...