About
Contact & Profiles
A5028408627
Research Areas
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Monoclonal and Polyclonal Antibodies Research
Freie Universität Berlin
2023
Abstract Presentation of antigenic peptides by major histocompatibility complex class II (MHC-II) proteins determines T helper cell reactivity. The MHC-II genetic locus displays a large degree allelic polymorphism influencing the peptide repertoire presented resulting protein allotypes. During antigen processing, human leukocyte (HLA) molecule HLA-DM (DM) encounters these distinct allotypes and catalyzes exchange placeholder CLIP exploiting dynamic features MHC-II. Here, we investigate 12...
10.1038/s41589-023-01316-3
article
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cc-by
Nature Chemical Biology
2023-05-04
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