A5026869826- Animal Genetics and Reproduction
- Pluripotent Stem Cells Research
- Reproductive Biology and Fertility
- Chromosomal and Genetic Variations
- Plant Molecular Biology Research
- Sperm and Testicular Function
- Reproductive Health and Technologies
Nanjing Medical University
2024-2025
PIWI-interacting RNAs (piRNAs) are small noncoding that almost exclusively expressed in germ cells to silence harmful transposons maintain genome stability. PIWIL4 is guided by its associated piRNAs transposable elements, where it recruits the DNA methylation apparatus and instructs de novo methylation. Herein, we identified a missense variant of (c.805 C>T p.R269W) two infertile males. Homozygous male mice carrying orthologous knock-in displayed elevated element expression aberrant gene...
Abstract Germ cell development depends on the capacity of somatic Sertoli cells to undergo differentiation into a mature state and establish germ cell‐specific blood–testis barrier (BTB). The BTB structure confers an immunological for meiotic postmeiotic cells, its dynamic permeability facilitates transient movement preleptotene spermatocytes through enter meiosis. However, regulatory factors involved in maturation how dynamics coordinate remain unclear. Here, we found histone deacetylase...