A5032226017- Mast cells and histamine
- Systemic Lupus Erythematosus Research
- Immune Cell Function and Interaction
- Cytokine Signaling Pathways and Interactions
- Atherosclerosis and Cardiovascular Diseases
- Monoclonal and Polyclonal Antibodies Research
- Wound Healing and Treatments
- Dermatology and Skin Diseases
- Urticaria and Related Conditions
- T-cell and B-cell Immunology
Inserm
2022-2024
Université Paris Cité
2022-2024
Centre de Recherche sur l'Inflammation
2022-2024
Centre National de la Recherche Scientifique
2022-2024
Délégation Paris 7
2024
Abstract Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by anti-nuclear autoantibodies whose production promoted autoreactive T follicular helper (TFH) cells. During SLE pathogenesis, basophils accumulate in secondary lymphoid organs (SLO), amplify autoantibody and progression through mechanisms that remain to be defined. Here, we provide evidence for a direct functional relationship between TFH cells during both humans mice. PD-L1 upregulation on IL-4 are...
Tissue-specific mouse models are essential tools to decipher the role of each cell compartment and/or their expressed genes in pathophysiology diseases. Here, we describe a new knock-in model allowing expression both fluorescent protein tdTomato and CRE recombinase selectively basophil under control Mcpt8 gene. These "CT-M8" mice did not show any abnormalities peripheral distribution major immune populations nor function. CT-M8 allowed identification basophils by immunofluorescence flow...
Objectives Discontinuation or continuation of maintenance immunosuppressive therapy (MIST) after a severe lupus nephritis (LN) requires measuring the risk relapse but reliable clinical and biological markers are lacking. The WIN-IgE study assesses value serum anti-dsDNA IgE autoantibodies as biomarker for prediction in LN. Methods is an ancillary WIN-Lupus ( NCT01284725 ), prospective controlled trial which evaluated discontinuation MIST 2–3 years class III IV±V LN with active lesions....
ABSTRACT An active resolution is critical to control the duration of inflammation and limit its pathological consequences. Defects in during wound healing allow emergence chronic wounds, a common complication elderly. Here, we show that basophils infiltrate periphery mouse skin wounds for at least three weeks, both phases healing. Depletion induces an increased secretion inflammatory molecules, accumulation activation pro-inflammatory leukocytes, delays response. Basophils particularly...
ABSTRACT Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by autoantibodies raised against nuclear antigens and whose production promoted autoreactive T follicular helper (TFH) cells. Basophils, accumulating in secondary lymphoid organs (SLO), amplify autoantibody progression through mechanisms to be defined. Here, we demonstrate that a functional relationship between TFH cells basophils occurs SLO during pathogenesis. On SLE patient blood basophils, PD-L1 expression...