A5079979571- Chemical Synthesis and Reactions
- Hemoglobin structure and function
- Radiation Dose and Imaging
- Synthesis and properties of polymers
- Polyamine Metabolism and Applications
- Radiology practices and education
- Radiomics and Machine Learning in Medical Imaging
- Neonatal Health and Biochemistry
- Genetic Syndromes and Imprinting
- Chemical Synthesis and Analysis
- Congenital heart defects research
- Parathyroid Disorders and Treatments
- Cancer, Hypoxia, and Metabolism
- Inorganic and Organometallic Chemistry
Yokohama City University
2025
Ohnishi Neurological Center
1989-1997
Abstract We report herein an efficient synthesis of fully Boc‐protected, up to 13‐meric polymer 1,3‐propanediamine. The was facilitated by one‐pot conversion (up six) N ‐Ns groups ‐Boc under conditions 1) PhSH and Cs 2 CO 3 for deprotection the Ns group, followed 2) Boc O protection. average yield per group extremely high, especially substrates with four six (94.6%–96.6%).
Abstract A convergent, iterative, and split-couple strategy for synthesis of homogeneous polymer 1,3-propanediamine (long-chain polyamine, LCPA) has been developed, by employing 1,3-dibromopropane as a glue in subunit couplings. By this synthetic strategy, 7-, 11-, 15-mer LCPAs were successfully synthesized. This solved problems that had arisen with previous methods, such variable reactivity poor reproducibility.
The mutations of the preproparathyroid hormone (preproPTH) gene have been reported to cause some cases familial isolated hypoparathyroidism (FIH). We investigated preproPTH five affected subjects three Japanese kindreds with FIH. mode inheritance in FIH two families was thought be autosomal dominant, and other probably inherited an recessive manner. Exons 1, 2 3 its exon-intron boundaries were analyzed either polymerase chain reaction single strand conformational polymorphism, or direct...