A5025488300- Microbial Fuel Cells and Bioremediation
- Iron Metabolism and Disorders
- Hemoglobinopathies and Related Disorders
- Erythrocyte Function and Pathophysiology
- Genetic Syndromes and Imprinting
- Plant Reproductive Biology
- Electrocatalysts for Energy Conversion
- Microbial Community Ecology and Physiology
- Protist diversity and phylogeny
- Biochemical Acid Research Studies
- Genomics and Phylogenetic Studies
- Cellular transport and secretion
- Reproductive Biology and Fertility
- Plant Molecular Biology Research
- Fuel Cells and Related Materials
- Wastewater Treatment and Nitrogen Removal
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
University of Cincinnati
2021-2025
TGFβ family ligands are synthesized as precursors consisting of an N-terminal prodomain and C-terminal growth factor (GF) signaling domain. After proteolytic processing, the typically remains noncovalently associated with GF, sometimes forming a high-affinity latent procomplex that requires activation. For ligand anti-Müllerian hormone (AMH), maintains interaction its GF does not render it latent. While can be displaced by type II receptor, AMHR2, nature GF:prodomain mechanism displacement...
Hepcidin, a peptide hormone that negatively regulates iron metabolism, is expressed by bone morphogenetic protein (BMP) signaling. Erythroferrone (ERFE) an extracellular binds and inhibits BMP ligands, thus positively regulating import indirectly suppressing hepcidin. This allows for rapid erythrocyte regeneration after blood loss. ERFE belongs to the C1Q/TNF-related family suggested adopt multiple oligomeric forms: trimer, hexamer, high molecular weight species. The basis how ligands...
Extracellular electron transfer (EET) – the process by which microorganisms electrons across their membrane(s) to/from solid-phase materials has implications for a wide range of biogeochemically important processes in marine environments. Though EET is thought to play an role oxidation inorganic minerals lithotrophic organisms, mechanisms involved solid particles are poorly understood. To explore genetic basis oxidative EET, we utilized genomic analyses and transposon insertion mutagenesis...
Extracellular electron transfer (EET), the process that allows microbes to exchange electrons in a redox capacity with solid interfaces such as minerals or electrodes, has been predominantly described use iron during respiration. In this work, we characterize physiology, genome, and electrochemical properties of two obligately heterotrophic marine were previously isolated from sediment cathode enrichments. Phylogenetic analysis isolate 16S rRNA genes showed strains, SN11 FeN1, belonging...
Hepcidin, a peptide hormone that negatively regulates iron metabolism, is expressed by bone morphogenetic protein (BMP) signaling. Erythroferrone (ERFE) an extracellular binds and inhibits BMP ligands, thus positively regulating import indirectly suppressing hepcidin. This allows for rapid erythrocyte regeneration after blood loss. ERFE belongs to the C1Q/TNF related (CTRP) family suggested adopt multiple oligomeric forms: trimer, hexamer, high molecular weight species. The basis how ligands...
Abstract Most TGFβ family ligands exist as procomplexes consisting of a prodomain noncovalently bound to growth factor (GF); Whereas some prodomains confer latency, the Anti-Müllerian Hormone (AMH) maintains remarkably high affinity for GF yet remains active. Using single particle EM methods, we show AMH consists two subdomains: vestigial prodomain-like fold and novel, helical bundle GF-binding domain, result an exon insertion 450 million years ago, that engages both receptor epitopes. When...
Abstract Disclosure: J.A. Howard: None. L. Hok: N.J. Sanford: R.L. Cate: K. Hart: Employee; Self; Regeneron Pharmaceuticals. E. Leach: D. Pepin: P.K. Donahoe: T.B. Thompson: Advisory Board Member; Oviva Therapeutics, Keros Therapeutics. The Anti-Mullerian hormone (AMH), a divergent member of the TGF-beta signaling superfamily, plays crucial roles in reproductive development and maintenance. Owing to its key role as negative feedback regulator folliculogenesis, AMH has garnered significant...
We report the complete, closed, circular genome of Halomonas sp. strain FeN2, a metabolically versatile electrotroph that was isolated from Catalina Harbor sediments. The 4.8-Mb contains 4,286 protein-coding genes and has complete glycolytic, tricarboxylic acid, glyoxylate, pentose phosphate, reductive phosphate pathways. FeN2 also for aerobic anaerobic (denitrification) respiration.