A5094312801- Plant Reproductive Biology
- Genetic Syndromes and Imprinting
- Cellular transport and secretion
- Plant Molecular Biology Research
- Reproductive Biology and Fertility
- Biochemical Acid Research Studies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
University of Cincinnati
2024-2025
TGFβ family ligands are synthesized as precursors consisting of an N-terminal prodomain and C-terminal growth factor (GF) signaling domain. After proteolytic processing, the typically remains noncovalently associated with GF, sometimes forming a high-affinity latent procomplex that requires activation. For ligand anti-Müllerian hormone (AMH), maintains interaction its GF does not render it latent. While can be displaced by type II receptor, AMHR2, nature GF:prodomain mechanism displacement...
Abstract Most TGFβ family ligands exist as procomplexes consisting of a prodomain noncovalently bound to growth factor (GF); Whereas some prodomains confer latency, the Anti-Müllerian Hormone (AMH) maintains remarkably high affinity for GF yet remains active. Using single particle EM methods, we show AMH consists two subdomains: vestigial prodomain-like fold and novel, helical bundle GF-binding domain, result an exon insertion 450 million years ago, that engages both receptor epitopes. When...
Abstract Disclosure: J.A. Howard: None. L. Hok: N.J. Sanford: R.L. Cate: K. Hart: Employee; Self; Regeneron Pharmaceuticals. E. Leach: D. Pepin: P.K. Donahoe: T.B. Thompson: Advisory Board Member; Oviva Therapeutics, Keros Therapeutics. The Anti-Mullerian hormone (AMH), a divergent member of the TGF-beta signaling superfamily, plays crucial roles in reproductive development and maintenance. Owing to its key role as negative feedback regulator folliculogenesis, AMH has garnered significant...