A5027986210- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Circular RNAs in diseases
- Mycobacterium research and diagnosis
- Cancer, Hypoxia, and Metabolism
- Genetic Associations and Epidemiology
- Kruppel-like factors research
- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- Lung Cancer Treatments and Mutations
- Grey System Theory Applications
- Lung Cancer Diagnosis and Treatment
- Cancer Research and Treatments
- Nanoplatforms for cancer theranostics
- Nitrogen and Sulfur Effects on Brassica
Guangdong Medical College
2018-2024
Macau University of Science and Technology
2024
Sun Yat-sen University
2023
Affiliated Hospital of Guangdong Medical College Hospital
2021-2022
Hubei University of Arts and Science
2020
Xiangyang Central Hospital
2020
Long non-coding RNAs (lncRNAs) have involved in human malignancies and played an important role gene regulations.The dysregulation of lncRNA MIR22HG has been reported several cancers.However, the esophageal adenocarcinoma (EAC) is poorly understood.Loss function approaches were used to investigate biological EAC cells.The effects on cell proliferation evaluated by WST-1 colony formation assays.The migration invasion examined using transwell assays.QRT-PCR Western blot evaluate mRNA protein...
Abstract Long non-coding RNAs play critical roles in the development of lung cancer by functioning as tumor suppressors or oncogenes. Changes expression LINC01279 have been associated with cell differentiation and human diseases. However, mechanism underlying activity tumorigenesis is not clear. Here, we analyzed function adenocarcinoma using clinical samples, xenografts, non-small-cell lines. We found that highly expressed may be considered a predictive factor for this cancer. Knockdown...
Esophageal adenocarcinoma (EAC) is one of the leading causes cancer-related death worldwide, and molecular biology this cancer remains poorly understood.Recent evidence indicates that long non-coding RNAs are dysregulated in a variety cancers including EAC.In study, siRNA mediated gene knockdown, Western blot, RT-PCR, as well oncogenic function assay were performed.We found cell proliferation, colony formation, invasion migration decreased after LINC00857 knockdown EAC lines.We also could...
Residual lesions and undetectable metastasis after insufficient radiofrequency ablation (iRFA) are associated with earlier new metastases poor survival in cancer patients, for induced aggressive tumor phenotype immunosuppression. Programmed cell death protein 1(PD-1) blockade has been reported to enhance the ablation-elicited antitumor immunity, but its ability eliminate incompletely ablated residual questioned. Here, we report a combined treatment modality post iRFA based on integrating an...
Observational studies have consistently shown a correlation between breast cancer (BC) and endometrial (EC). Despite these findings, the causal relationship cancers has not been clearly defined. This research employed bidirectional two-sample Mendelian randomization to explore genetic causality BC EC. Genetic instruments for were derived from Breast Cancer Association Consortium genome-wide association summary statistics, while EC, data sourced Endometrial Consortium, Epidemiology of UK...
Cancer is closely related to age, and the incidence of cancer increases with age. However, there are few studies on relationship between age clinical characteristics lung cancer.We collected all consecutive cases from 2012 2017 in our hospital divided them into 6 groups according their ages: ≤40 y/o, 41~50 51~60 61~70 71~80 y/o >80 y/o. The prognosis these patients were evaluated.There 1143 diagnosed 2017. There more non-smokers (p<0.01), stage IV (p<0.01) anaplastic lymphoma kinase (ALK)...
Objective: To investigate the effects of pre-B lymphocytic leukemia transcription factor (PBX1) expression on apoptosis, reactive oxygen species (ROS) content and transcriptional activation 3 (STAT3) signaling pathway lung cancer cells. Methods: Real-time quantitative polymerase chain reaction was used to detect level PBX1 in tissues adjacent tissues. The correlation between clinical pathological parameters patients were analyzed. Western blot protein human cell lines, including A549,...
Background: Long non-coding RNAs (lncRNAs) have involved in human malignancies and played an important role gene regulations. The dysregulation of lncRNA MIR22HG has been reported several cancers. However, the esophageal adenocarcinoma (EAC) is poorly understood. Methods: Loss function approaches were used to investigate biological EAC cells. effects on cell proliferation evaluated by WST-1 colony formation assays. MIR22HGon migration invasion examined using transwell QRT-PCR Western blot...
Abstract Long non-coding RNAs play critical roles in the development of lung cancer by functioning as tumor suppressors or oncogenes. Changes expression LINC01279 have been associated with cell differentiation and human diseases. However, mechanism underlying activity tumorigenesis is not clear. Here, we analyzed function adenocarcinoma using clinical samples, xenografts, non-small-cell lines. We found that highly expressed may be considered a predictive factor for this cancer. Knockdown...
Abstract Background: In human lung adenocarcinoma (LUAD) tissues, Long noncoding RNA LINC01279 is significantly upregulated. However, the functions of in LUAD yet to be clarified. Methods: situ hybridization was employed investigate difference between expression and normal tissues. The result verified by qRT-PCR. Cytoplasmic nuclear experiments showed that mainly located cytoplasm cancer cells. loss function experiment could inhibit proliferation, colony formation, invasion migration...