A5041176677- SARS-CoV-2 and COVID-19 Research
- Viral gastroenteritis research and epidemiology
- Influenza Virus Research Studies
- Respiratory viral infections research
- vaccines and immunoinformatics approaches
- Animal Virus Infections Studies
- Immunotherapy and Immune Responses
- Viral Infections and Outbreaks Research
- Immune responses and vaccinations
- Monoclonal and Polyclonal Antibodies Research
University of Cambridge
2023-2025
The threat of spillovers coronaviruses associated with the severe acute respiratory syndrome (SARS) from animals to humans necessitates vaccines that offer broader protection sarbecoviruses. By leveraging a viral-genome-informed computational method for selecting immune-optimized and structurally engineered antigens, here we show single antigen based on receptor binding domain spike protein sarbecoviruses elicits broad humoral responses against SARS-CoV-1, SARS-CoV-2, WIV16 RaTG13 in mice,...
The accelerated development of the first generation COVID-19 vaccines has saved millions lives, and potentially more from long-term sequelae SARS-CoV-2 infection. most successful vaccine candidates have used full-length spike protein as an immunogen. As expected RNA viruses, new variants evolved quickly replaced original wild-type SARS-CoV-2, leading to escape natural infection or induced immunity provided by sequence. Next that confer specific targeted broadly neutralising epitopes on...
<title>Abstract</title> A panzootic of H5Nx avian influenza viruses has severely affected poultry and wild bird populations, resulting in multiple mammalian spillovers, including mild to fatal human infections caused by antigenically distinct diverse virus clades. The unpredictable nature spillover events drifted hinders our ability effectively respond the heightened risk human-to-human transmission. Stockpiled strain-specific H5 whole virus-based vaccines provide limited breadth reduced...
ABSTRACT The increasing global spread of the highly pathogenic avian influenza (HPAI) A/H5 viruses poses a serious public health threat. Circulating clade 2.3.4.4b have demonstrated rapid transcontinental dissemination, extensive reassortment, epizootic and potential sustained mammal-to-mammal transmission, signifying heightened risk becoming human pathogen high consequence. A broadly protective, future-proof vaccine against multiple clades H5 is urgently needed for pandemic preparedness....