A5043355990- ATP Synthase and ATPases Research
- Ultrasound in Clinical Applications
- Ion channel regulation and function
- Fuel Cells and Related Materials
- Drug-Induced Hepatotoxicity and Protection
- Cardiac Imaging and Diagnostics
- Mitochondrial Function and Pathology
- Biomedical Research and Pathophysiology
- Receptor Mechanisms and Signaling
- Evaluation and Optimization Models
- Diet and metabolism studies
- Tunneling and Rock Mechanics
- Occupational Health and Safety Research
- Venomous Animal Envenomation and Studies
- Hip and Femur Fractures
- Silymarin and Mushroom Poisoning
Peking University Cancer Hospital
2025
Peking University
2025
Kunming Medical University
2025
China Pharmaceutical University
2024
Beijing Anzhen Hospital
2024
Chongqing Medical University
2024
Capital Medical University
2024
Chronic overconsumption of lipids followed by their excessive accumulation in the heart leads to cardiomyopathy. The cause lipid-induced cardiomyopathy involves a pivotal role for proton-pump vacuolar-type H+-ATPase (v-ATPase), which acidifies endosomes, and lipid-transporter CD36, is stored acidified endosomes. During lipid overexposure, an increased influx into cardiomyocytes sensed v-ATPase, then disassembles, causing endosomal de-acidification expulsion CD36 from endosomes toward...
Abstract Screening bioactive compounds from natural sources, including animals and plants, is a valuable strategy for identifying novel anti-tumor agents. α-Toxin BmK-M9, key component of scorpion venom, has received limited attention regarding its potential anti-cancer effects underlying mechanisms in breast cancer. This study investigates the BmK-M9 cancer using vitro experiments nude mouse model. mRNA sequencing was performed to identify affected signaling pathways, while Western blotting...
As a key component of infrastructure, the construction safety deep excavation is particularly important. In order to improve and stability Deep construction, research on risk resistance rapid recovery capabilities projects carried out. By introducing concept resilience, we analyze factors that affect resilience projects, use Bayesian networks establish model expresses causal relationship between factors, learn parameters network through data samples collected surveys; by adjusting Analyze...
Silybin, a milk thistle extract, is flavonolignan compound with hepatoprotective effect. It commonly used in dietary supplements, functional foods, and nutraceuticals. However, the metabolism of silybin has not been systematically characterized organisms to date. Therefore, we established novel high-performance liquid chromatography quadrupole time-of-flight mass spectrometry method analyze identify prototype metabolites rats. In total, 29 (of 32) new metabolic pathways 56 59) unreported...