A5078457911- Stress Responses and Cortisol
- Alzheimer's disease research and treatments
- Neuroscience and Neuropharmacology Research
- Estrogen and related hormone effects
- Neuroendocrine regulation and behavior
- Neuroinflammation and Neurodegeneration Mechanisms
- Medical Research and Treatments
- Phosphodiesterase function and regulation
- Traditional Chinese Medicine Studies
- Cholinesterase and Neurodegenerative Diseases
- Healthcare and Venom Research
- Menopause: Health Impacts and Treatments
Shandong First Medical University
2023-2025
Academy of Medical Sciences
2023
Alzheimer disease (AD) and depression often cooccur, inhibition of phosphodiesterase-4 (PDE4) has been shown to ameliorate neurodegenerative illness. Therefore, we explored whether PDE4 inhibitor rolipram might also improve the symptoms comorbid AD depression.APP/PS1/tau mice (10 months old) were treated with or without daily i.p. injections for 10 days. The animal groups compared in behavioral tests related learning, memory, anxiety, depression. Neurochemical measures conducted explore...
Ethnopharmacological relevance: The traditional Chinese medicine formula Danggui-Shaoyao-San (DSS) has been reported to have estrogen-like effects and therapeutic on the symptoms of Alzheimer's disease (AD).Aim study: To explore whether central oxytocin neuroendocrine system is involved in modulating DSS cognition neuropsychiatric hebaviors female AD rats, investigate pharmacokinetics paeoniflorin ferulic acid rats with treatment.Material methods: (1.2, 3.2, 8.6g/kg/day) was orally...
Introduction The prevalence of Alzheimer’s disease (AD) is significantly gender-differentiated, with the number female AD patients far exceeding that males, accounting for two-thirds total prevalence. Although postmenopausal mice have been shown to more prominent pathologic features and memory impairments than normal mice, relevant molecular mechanisms leading these outcomes not well elucidated. In present study, we used disturbance excitation-inhibition balance in brain as an entry point...