A5100451142- Wound Healing and Treatments
- Cancer-related molecular mechanisms research
- Animal Virus Infections Studies
- Diabetic Foot Ulcer Assessment and Management
- Virus-based gene therapy research
- Tribology and Lubrication Engineering
- Hippo pathway signaling and YAP/TAZ
- Viral gastroenteritis research and epidemiology
- Mesenchymal stem cell research
- Renal cell carcinoma treatment
- RNA Interference and Gene Delivery
- Inflammasome and immune disorders
- Immunotherapy and Immune Responses
- Renal and related cancers
- Industrial Automation and Control Systems
- Nanoplatforms for cancer theranostics
- Angiogenesis and VEGF in Cancer
- Salmonella and Campylobacter epidemiology
- Endoplasmic Reticulum Stress and Disease
- Chemical and Physical Properties in Aqueous Solutions
- Traditional Chinese Medicine Studies
- Molecular Biology Techniques and Applications
- Lattice Boltzmann Simulation Studies
- vaccines and immunoinformatics approaches
- Escherichia coli research studies
Anhui Academy of Agricultural Sciences
2022-2024
Wuhan University
2023
Huazhong University of Science and Technology
2023
Animal Science Research Institute
2023
Nanjing University of Science and Technology
2023
Shandong First Medical University
2023
Shenzhen University
2023
Poultry Research Institute
2023
Hunan Agricultural University
2022
Second Military Medical University
2009-2020
Impaired wound healing frequently occurs in diabetes mellitus (DM) and is implicated impaired angiogenesis. Long non-coding RNA (lncRNA) H19 has been reported as being reduced DM played a critical role inducing Thus, we hypothesized that may affect streptozotocin (STZ)-induced diabetic mice transfused with autologous blood preserved standard preservative fluid or modified fluid. Fibroblasts injured skin were isolated cultured vitro. After location of fibroblasts using fluorescence situ...
Immune checkpoint blockade has been regarded as a highly promising cancer immunotherapy approach. However, inefficient immune cell infiltration and the immunosuppressive tumor microenvironment (TME) remain significant causes of low clinical response rates. Here, we identified that trivalent chromium irons (Cr3+) could enhance cells including M1-type tumor-associated macrophages CD8+ T cells. Mechanistically, this effect is dependent on expression macrophage inflammatory protein-1α (MIP-1α)...
Pyroptosis is a recently characterized inflammatory form of programmed cell death that thought to be involved in the pathogenesis perioperative neurocognitive disorders (PND). Elamipretide (SS-31), mitochondrial-targeted peptide with multiple pharmacological properties, including anti-inflammatory activity, has been demonstrated protect against many neurological diseases. However, effect elamipretide on pyroptosis PND not studied. We established an animal model by performing exploratory...
Impaired wound healing is a debilitating complication of diabetes. The long non-coding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) has been recognized to be differentially expressed in various diseases. However, its underlying mechanism diabetes not fully understood. Notably, we aim examine the expression MALAT1 diabetic mice and role involving hypoxia-inducible factor-1α (HIF-1α) signaling pathway with modified autologous blood preservative solution...
The high mortality rate of weaned piglets infected with porcine epidemic diarrhea virus (PEDV) poses a serious threat to the pig industry worldwide, demanding urgent research efforts related developing effective antiviral drugs prevent and treat PEDV infection. Small molecules can possibly spread infection by targeting specific vital components pathogen's genome. Main protease (Mpro, also named 3CL protease) plays essential roles in replication has emerged as promising target for inhibition...
There is ambiguity concerning the distribution of neurons that express ghrelin receptor (GHSR) in medulla oblongata. In current study we used a sensitive nonradioactive method to investigate GHSR mRNA by situ hybridization. Strong expression gene was confirmed facial nucleus (FacN, 7), dorsal vagal complex (DVC), and semicompact (but not compact) ambiguus (AmbSC AmbC). addition, found other regions, where it had been described before. GHSR-positive were observed gustatory rostral tractus...
Porcine epidemic diarrhea virus (PEDV) mainly causes acute and severe porcine (PED), is highly fatal in neonatal piglets. No reliable therapeutics against the infection exist, which poses a major global health issue for Luteolin flavonoid with anti-viral activity toward several viruses.
The present study was performed to evaluate the impacts of tannic acid (TA) supplementation at different levels on growth performance, physiological, oxidative and immunological metrics, ruminal microflora Xiangdong black goats. Twenty-four goats were randomly assigned four dietary treatments: control (CON, basal diet), low-dose TA group [TAL, 0.3 % dry matter (DM)], mid-dose (TAM, 0.6 DM), high-dose (TAH, 0.9 DM). Results showed that performance unaffected (P > 0.05) by adding TA, whilst...
During deep-sea mining, the heavy metals pollutants can cause contamination in marine environment. In this paper, multiphasic coupling model is established to describe metal migration process during which takes effects of convection-diffusion, adsorption-desorption and sedimentation-resuspension aquatic environment into full consideration. Due advantages Lattice Boltzmann method, it adopted numerically solve achieve simulation for mining. addition, taking Cadmium as an example, concentration...
Porcine epidemic diarrhea virus (PEDV) infection causes severe in pigs and can be fatal newborn piglets. Exosomes are extracellular vesicles secreted by cells that transfer biologically active proteins, lipids, RNA to neighboring or distant cells. Herein, the morphology, particle size, secretion of exosomes derived from a control PEDV-infected group examined, followed proteomic analysis exosomes. The results show Vero had typical cup-shaped structure. average size was 112.4 nm, whereas 150.8...
// Huan Wang 1, * , Yufeng Feng 2, Xiaoju Jin 3 Rong Xia 4 Yong Cheng 1 Xiaoqian Liu Nana Zhu Xun Zhou Lei Yin and Jianrong Guo Department of Anesthesiology, Gongli Hospital, The Second Military Medical University, Shanghai 200135, China 2 First Affiliated Hospital Xiamen 361003, Yijishan to Wannan College, Wuhu 241001, Transfusion Department, Huashan Fudan 200040, Co-first authors Correspondence to: Guo, email: gjr8259@yeah.net Keywords: diabetic wound closure; blood re-infusion;...
Transfusion of autologous blood is a timesaving, convenient, safe, and effective therapy from clinical perspective, often employed for the treatment diabetic patients. Stabilization HIF-1α has been widely reported to be critical factor in improvement wound healing diabetes. Therefore, our study reveals roles improved diabetes, through transfusion mouse model. Initially, BALB/c mice were subjected streptozotocin model establishment. Diabetic transfused with or standard perfusion culture...
The porcine epidemic diarrhea virus (PEDV) has catastrophic impacts on the global pig industry. However, there is no consensus primary receptor associated with PEDV invasion of host cells. An increasing number studies have reported that invading cells may require collaboration between multiple receptors and to better understand virus-host interaction during entry, surface plasmon resonance (SPR) assays are performed investigate relevant factors interacting spike-1 protein (S1) in Vero...
To investigate the antitumor activity of tumor lysate-pulsed dendritic cells vaccine in RM-1 prostate cancer mice model with survival time calculated and size measured DC therapy. C57BL/6 were immunized on dorsal flank by s.c. inoculation Lysate-DC, ova-DC, non-DC day −7. On 0, 2×106 (H-2b) injected pre-treated modified DCs, correspondingly. DTH assay was performed DCs. In partial test, for determination which immune required activity, immunodepleted CD4, CD8, or natural killer (NK) NK1.1...
Ethnopharmacological relevance: The traditional Chinese medicine formula Danggui-Shaoyao-San (DSS) has been reported to have estrogen-like effects and therapeutic on the symptoms of Alzheimer's disease (AD).Aim study: To explore whether central oxytocin neuroendocrine system is involved in modulating DSS cognition neuropsychiatric hebaviors female AD rats, investigate pharmacokinetics paeoniflorin ferulic acid rats with treatment.Material methods: (1.2, 3.2, 8.6g/kg/day) was orally...