A5025499099- Nutritional Studies and Diet
- Endometriosis Research and Treatment
- Cytokine Signaling Pathways and Interactions
- Psoriasis: Treatment and Pathogenesis
- Asthma and respiratory diseases
- BRCA gene mutations in cancer
- Tuberculosis Research and Epidemiology
- bioluminescence and chemiluminescence research
- Antibiotics Pharmacokinetics and Efficacy
- Aortic aneurysm repair treatments
- Reproductive System and Pregnancy
- Estrogen and related hormone effects
- Antimicrobial agents and applications
- Global Cancer Incidence and Screening
- Phenothiazines and Benzothiazines Synthesis and Activities
- Cancer Treatment and Pharmacology
- Genetic Associations and Epidemiology
- Dermatologic Treatments and Research
- Antibiotic Resistance in Bacteria
- Retinoids in leukemia and cellular processes
- Acute Lymphoblastic Leukemia research
- Inflammatory Biomarkers in Disease Prognosis
- Uterine Myomas and Treatments
- Protein Kinase Regulation and GTPase Signaling
- Cancer therapeutics and mechanisms
Vanderbilt University Medical Center
2023-2025
Vanderbilt University
2025
University of Pittsburgh
2024
Rutgers, The State University of New Jersey
2024
VA Pittsburgh Healthcare System
2024
Nara Medical University Hospital
2024
Columbia University
1991
Scripps Clinic
1988-1990
Abstract Self‐assembling chemotherapeutic agents are mixtures of relatively nontoxic precursors that can combine chemically under physiological conditions to form products with greater cytotoxic and/or antimicrobial activity than either the precursors. Combinations more rapidly in or near target (tumor, pathogen, virally infected cell) normal tissues will exhibit target‐selective synergism, thus exhibiting an antitarget selectivity is selectivities product (e.g., a hydrazone) and precursor...
ABSTRACT Keloids are raised scars that grow beyond original wound boundaries, resulting in pain and disfigurement. Reasons for keloid development not well-understood, current treatment options limited. more likely to occur darker-skinned individuals of African Asian descent than Europeans. We performed a genome-wide association study (GWAS) examining risk across within continental ancestry groups, incorporating 7,837 cases 1,593,009 controls. detected 21 novel independent loci the...
Abstract Background: Lung cancer risk attributable to smoking is dose dependent, yet few studies examining a polygenic score (PRS) by interaction have included comprehensive lifetime pack-years smoked. Methods: We analyzed data from participants of European ancestry in the Framingham Heart Study Original (n = 454) and Offspring 2,470) cohorts enrolled 1954 1971, respectively, followed through 2018. built PRS for lung using participant genotyping genome-wide association study summary...
Previous studies have described a dicationic anticarcinoma agent that can chemically assemble in situ from monocationic phosphonium salts. The chemical combination of these precursors the micromolar concentration range, occurring after their uptake by cells, was probably responsible for synergistic inhibition cell growth and selective cytotoxicity to Ehrlich ascites murine carcinoma cells relative untransformed epithelial cells. Here, we report product forms this assembly reaction is an...
Background Genetic polymorphisms have been associated with risk of antituberculosis treatment toxicity. We characterized associations adverse events and failure/recurrence among adults treated for tuberculosis in Brazil. Methods Participants were followed Regional Prospective Observational Research Tuberculosis (RePORT)-Brazil. included persons culture-confirmed drug-susceptible pulmonary who started between 2015 2019, eligible pharmacogenetics. Treatment 2 months isoniazid, rifampin or...
Genetic polymorphisms have been associated with risk of anti-tuberculosis treatment toxicity. We characterized associations adverse events and failure/recurrence among adults treated for tuberculosis in Brazil. Participants were followed Regional Prospective Observational Research Tuberculosis (RePORT)-Brazil. included persons culture-confirmed drug-susceptible pulmonary who started between 2015-2019, evaluable pharmacogenetics. Treatment 2 months isoniazid, rifampin or rifabutin,...
<title>Abstract</title> Psoriasis, an immune-mediated skin disease characterized by erythematous plaques, is often associated with chronic lung diseases that impair pulmonary function. To investigate a potential genetic link between psoriasis and function, we analyzed 63 previously reported psoriasis-associated single nucleotide polymorphisms (SNPs) for their associations both function measurements using data from the UK Biobank (UKBB) Vanderbilt University Medical Center (BioVU). Our...
Endometriosis is a complex and heterogeneous condition affecting 10% of reproductive-age women, yet, it often goes undiagnosed for several years. Limited observed heritability (7%) large genetic association studies may be attributable to underlying heterogeneity disease mechanisms. Therefore, we conducted this study investigate associations across sub-phenotypes endometriosis. We performed unsupervised clustering 4,078 women with endometriosis based on known risk factors, symptoms,...
ABSTRACT Background Abdominal aortic aneurysm (AAA) is a disease associated with the pathophysiologic degradation of tunica media resulting in dilatation, systemic inflammation, and dysregulated hemostasis. Beyond role its initiating primary hemostasis, platelets are source ROS, inflammatory cytokines growth factors necessary for angiogenesis vascular remodeling. Although contribute to progression established aneurysms, their initiation AAA remains undefined. Methods Low density lipoprotein...
Abstract We report the findings of a genome-wide association study (GWAS) meta-analysis endometriosis consisting large portion (31%) non-European samples across 14 biobanks worldwide as part Global Biobank Meta-Analysis Initiative (GBMI). identified 45 significant loci using wide phenotype definition, seven which are previously unreported and detected first locus ( POLR2M ) among only African-ancestry. Our narrow phenotypes surgically confirmed case definitions for analyses replicated known...
ABSTRACT Introduction The common genetic underpinnings of psoriasis and pulmonary comorbidities have yet to be explored. Material Methods In this cross‐sectional study, we investigated the single‐nucleotide polymorphisms (SNPs) associated with their relationship function using data from UK Biobank (UKBB) Vanderbilt University Medical Center (BioVU). Results Out 63 psoriasis‐associated SNPs identified in previous genome‐wide association studies within European population, successfully 53...
<p>Supplemental Figure 4: Overlaid histograms showing the distribution of polygenic risk scores by case/non-case status</p>
<p>Supplemental Figure 1: Sample timeline of data collection, timing examinations (i.e., when smoking status is updated), and lung cancer incidence in an FHS Offspring participant who attended 9 was diagnosed with 2001.</p>
<div>AbstractBackground:<p>Lung cancer risk attributable to smoking is dose dependent, yet few studies examining a polygenic score (PRS) by interaction have included comprehensive lifetime pack-years smoked.</p>Methods:<p>We analyzed data from participants of European ancestry in the Framingham Heart Study Original (<i>n</i> = 454) and Offspring 2,470) cohorts enrolled 1954 1971, respectively, followed through 2018. We built PRS for lung using participant...
<div>AbstractBackground:<p>Lung cancer risk attributable to smoking is dose dependent, yet few studies examining a polygenic score (PRS) by interaction have included comprehensive lifetime pack-years smoked.</p>Methods:<p>We analyzed data from participants of European ancestry in the Framingham Heart Study Original (<i>n</i> = 454) and Offspring 2,470) cohorts enrolled 1954 1971, respectively, followed through 2018. We built PRS for lung using participant...
<p>Supplemental Figure 2: Overlaid histograms of pack-years smoked by smoking status. This plot shows that currently individuals tended to incur more than formerly individuals.</p>
<p>Supplemental Figure 2: Overlaid histograms of pack-years smoked by smoking status. This plot shows that currently individuals tended to incur more than formerly individuals.</p>
<p>Supplemental Figure 1: Sample timeline of data collection, timing examinations (i.e., when smoking status is updated), and lung cancer incidence in an FHS Offspring participant who attended 9 was diagnosed with 2001.</p>
<p>Supplemental Figure 3: PRS Model fit by p-value threshold. High resolution plots displaying the -log10(p-value) of association between lung cancer and in FHS sample (y-axis) versus threshold below which all SNPs with p-values for their individual base (OncoArray Consortium) were included (x-axis).</p>
<p>Supplemental Figure 4: Overlaid histograms showing the distribution of polygenic risk scores by case/non-case status</p>
<p>Supplemental Figure 3: PRS Model fit by p-value threshold. High resolution plots displaying the -log10(p-value) of association between lung cancer and in FHS sample (y-axis) versus threshold below which all SNPs with p-values for their individual base (OncoArray Consortium) were included (x-axis).</p>
Abstract Purpose: While risk factors for lung cancer incidence are well established, our understanding of driving an increased among Black/African American populations remains incomplete. Methods: We assembled data from five U.S. case-control studies matched on race, gender and age: the Southern Community Cohort Study, Inflammation, Health, Ancestry Lung Epidemiology study, Northern California Cancer three Detroit area studies, NCI-Maryland Study. Incident cancers were ascertained state...