A5103045728- Trypanosoma species research and implications
- Vector-borne infectious diseases
- Vector-Borne Animal Diseases
- Insect symbiosis and bacterial influences
- Research on Leishmaniasis Studies
- Parasitic Infections and Diagnostics
- Viral Infections and Vectors
- Bacteriophages and microbial interactions
- Toxoplasma gondii Research Studies
- Insect and Pesticide Research
- Plant Virus Research Studies
- Parasites and Host Interactions
- Extracellular vesicles in disease
- Helminth infection and control
- Hydrogels: synthesis, properties, applications
- Redox biology and oxidative stress
- Hip disorders and treatments
- Insect Pest Control Strategies
- vaccines and immunoinformatics approaches
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Research studies in Vietnam
- Organic Food and Agriculture
- Microbial infections and disease research
- Zoonotic diseases and public health
- Copper-based nanomaterials and applications
Texas A&M University
2012-2024
Obihiro University of Agriculture and Veterinary Medicine
2011-2023
Hanoi University of Mining and Geology
2023
Université Paris Cité
2021-2022
Inserm
2021-2022
Ministry of Agriculture and Rural Development
2021
Department of Animal Health
2021
National Economics University
2020
Changwon National University
2018
Vietnam National University of Agriculture
2013-2016
Lyme disease (LD) caused by Borrelia burgdorferi is among the most important human vector borne diseases for which there no effective prevention method. Identification of tick saliva transmission factors LD agent needed before highly advocated antigen-based vaccine could be developed. We previously reported conserved Ixodes scapularis ( Ixs ) serpin (S) 17 S17) was secreted B . infected nymphs. Here, we show that S17 promote feeding and enhances colonization host. not part a redundant...
The clinical (re)development of bacteriophage (phage) therapy to treat antibiotic-resistant infections faces the challenge understanding dynamics phage-bacteria interactions in vivo context. Here, we develop a general strategy coupling vitro and experiments with mathematical model characterize interplay between phage bacteria during pneumonia induced by pathogenic strain Escherichia coli. allows estimation several key parameters for therapeutic efficacy. In particular, it quantifies impact...
Đa hình gen kháng nguyên bạch cầu người (HLA) lớp II đóng vai trò quan trọng trong đáp ứng miễn dịch virus và có mối tương với nguy cơ nhiễm viêm gan C (HCV). Nghiên cứu này nhằm đánh giá liên giữa đa đơn nucleotide (SNP) rs2856718 của HLA-DQ HCV một số đặc điểm lâm sàng bệnh nhân C. Mẫu máu từ 101 127 khỏe mạnh (nhóm đối chứng) đã được thu thập xác định kiểu bằng phương pháp TaqMan Realtime-PCR. Tỷ lệ các AA, GA GG lần lượt là 21,8%, 45,5% 32,7% ở nhóm C; 19,7%, 48% 32,3% chứng, không sự...
During sporulation, Bacillus subtilis redeploys the division protein FtsZ from midcell to cell poles, ultimately generating an asymmetric septum. Here, we describe a sporulation-induced protein, RefZ, that facilitates switch medial polar ring placement. The artificial expression of RefZ during vegetative growth converts rings into spirals, arcs, and foci, leading filamentation lysis. Mutations in specifically suppress RefZ-dependent inhibition, suggesting may target FtsZ. cells lacking are...
Cuprous oxide (Cu2O) nanostructure has been synthesized using an electrochemical method with a two-electrode system. Cu foils were used as electrodes and NH2(OH) was utilized the reducing agent. The effects of pH applied voltages on morphology product investigated. optical properties Cu2O particles characterized scanning electron microscopy, x-ray diffraction, diffuse reflectance spectra. nanostructures that formed in vicinity anode at 2 V = 11 showed high uniform distribution, small size,...
Tick serine protease inhibitors (serpins) play crucial roles in tick feeding and pathogen transmission. We demonstrate that Ixodes scapularis (Ixs) nymph saliva serpin (S) 41 (IxsS41), secreted by Borrelia burgdorferi (Bb)-infected ticks at high abundance, is involved regulating evasion of host innate immunity promoting colonization Bb. Recombinant (r) proteins were expressed Pichia pastoris, substrate hydrolysis assays used to determine. Ex vivo (complement hemostasis function related) (paw...
Since facing outbreaks of severe acute respiratory syndrome and avian influenza A in 2003, Vietnam has increasingly applied a One Health approach to address emerging infectious diseases animal origin. Here, we reflect on the challenges opportunities context zoonoses, food safety, antimicrobial resistance, drawing stocktake training, policy, research Vietnam. We also report results virtual consultation workshop held July 2021 with representatives from 32 institutions explore future...
A total of 231 serum samples were collected from sheep (n=9), goats (n=99) and cattle (n=123) in northeastern KwaZulu-Natal, South Africa. Trypanosome infection was detected using Trypanosoma brucei crude antigen (TbbCA) T. congolense (TcoCA) ELISA assays. Recombinant (T. evansi GM6 which consisted 4 repeat domains, TeGM6-4r) immunochromatographic test (ICT) also used. Crude ELISA, TeGM6-4r-ELISA ICT 27.3%, 29% 19.9% trypanosome seropositive samples, respectively. prevalence 35.8–46.3%...
Ixodes scapularis is a blood-feeding obligate ectoparasite responsible for transmitting the Lyme disease (LD) agent, Borrelia burgdorferi. During feeding process, I. injects B. burgdorferi into host along with its saliva, facilitating transmission and colonization of LD agent. Tick calreticulin (CRT) one earliest tick saliva proteins identified currently utilized as biomarker bites. Our recent findings revealed elevated levels CRT in proteome burgdorferi-infected nymphs compared to...
Water buffalo (WB) is an important domestic animal in Vietnam. This study utilized a card agglutination test to investigate seroprevalence of surra WB population. Sera were collected from 585 4 different regions Cao Bang and Thai Nguyen Provinces. Among them, 131 samples (22.4%) positive for surra. The highest prevalence (24.6%) was found among 3 5 years old WB. Buffaloes less than had the lowest (15.6%). 27 abortion cases, 9 (33.3%) positive. For treatment surra, Berenil® demonstrated 100%...
In Mongolia, horses play important roles, not only in livestock production, but also terms of culture, tradition, and Mongolian beliefs. Although the presence non-tsetse-transmitted horse trypanosomoses, which are caused by infections with Trypanosoma evansi (surra) T. equiperdum (dourine), has been reported country, whether there is a nationwide epidemic these infectious diseases unknown. present study, surveillance trypanosomoses was performed. The sample sizes for each province, whole...
Wound healing has been extensively studied through the lens of inflammatory disorders and cancer, but limited attention given to hematophagy arthropod-borne diseases. Hematophagous ectoparasites, including ticks, subvert wound response maintain prolonged attachment facilitate blood-feeding. Here, we unveil a strategy by which extracellular vesicles (EVs) ensure blood-feeding arthropod survival in three medically relevant tick species. We demonstrate single cell RNA sequencing murine genetics...
This paper presents a survey dataset on factors influencing farmers' intention to produce organic farming in Hanoi, Vietnam. The was designed based the theoretical integration model of theory planned behavior (TPB) and norm activation (NAM) including 7 factors, 33 items inherited from previous studies collect information respondents 5 other used find out respondent's characteristic include: gender, age, educational qualification, experience annual income. Questionnaires were sent directly...
Sexual stage induction under in vitro conditions is useful for biological and molecular studies of Babesia parasites. Therefore, the present study, we induced B. ovata tick stages using chemical inducers: xanthurenic acid (XA), dithiothreitol (DTT) tris (2-carboxyethyl) phosphine (TCEP) at 27 °C or 37 conditions. Cultures low temperature (27 °C) treated with XA/TCEP a large number extra-erythrocytic merozoites, which transformed into round shape cells 12–24 h post-induction (pi). However,...
Abstract Background Schistosoma japonicum , which inhabits the mesenteric vein of mammalian hosts for about 20 to 30 years, is subjected oxidative stresses from host defense mechanism during their intra-mammalian stages. To counteract this immune attack, parasite utilizes antioxidant system survival inside host. Peroxiredoxins (Prxs), thiol-specific proteins, play an essential role protecting against stress by reducing hydrogen peroxide water. Only three types 2-Cys Prxs have been previously...
Bovine babesiosis is a tick-transmitted disease caused by intraerythrocytic protozoan parasites of the genus Babesia. Its main causative agents in Americas are Babesia bigemina and bovis, while ovata affects cattle Asia. All species secrete proteins stored organelles apical complex, which involved all steps invasion process vertebrate host cells. Unlike other apicomplexans, have dense granules, babesia instead large, round intracellular called spherical bodies. Evidence suggests that from...
Trypanosoma congolense is a major livestock pathogen in Africa, causing large economic losses with serious effects on animal health. Reliable serodiagnostic tests are therefore urgently needed to control T. infection. In this study, we have identified one protein as new candidate antigen. The 46.4 kDa (TcP46, Gene ID: TcIL3000.0.25950) expressed 5.36 times higher metacyclic forms than epimastigote forms. complete nucleotide sequences of TcP46 contained an open reading frame 1,218 bp....