A5115441708- Pharmaceutical studies and practices
- Epilepsy research and treatment
- Cardiovascular Issues in Pregnancy
- Pharmacological Effects and Toxicity Studies
- Cardiac Arrhythmias and Treatments
Objective - To establish an optimized sotalol dosing strategy for fetal tachycardia by using a pregnancy computational model dose simulations. Methods A physiologically-based model, including pregnancy-related changes and placental transfer values, was established verified. Simulations of the current advises prospective scenarios were performed. avoid maternal dose-related toxicity (QT-prolongation) we aimed concentrations <2.5 mg/L. Based on neonatal concentration-effect data, Ctrough...
Background Carbamazepine (CBZ) and valproic acid (VPA) are long-standing treatments for epilepsy in children. Interestingly, they display unique drug disposition characteristics maturation of metabolizing enzymes further complicates personalized dosing. Physiologically-based pharmacokinetic (PBPK) modeling includes these mechanisms is hence a promising tool to optimize Our aim better support pediatric dosing CBZ VPA. Methods All VPA simulations were conducted with Simcyp, using available...