A5050621637- Alcoholism and Thiamine Deficiency
- Estrogen and related hormone effects
- Cardiovascular Health and Disease Prevention
- Cardiovascular Disease and Adiposity
- Electrolyte and hormonal disorders
- PI3K/AKT/mTOR signaling in cancer
- Cardiac, Anesthesia and Surgical Outcomes
Tulane University
2024
BACKGROUND: Arterial stiffness is a cardiovascular risk factor and dramatically increases as women transition through menopause. The current study assessed whether mouse model of menopause arterial in similar manner to aging activation the G-protein–coupled estrogen receptor could reverse stiffness. METHODS: Female C57Bl/6J mice were ovariectomized at 10 weeks age or aged 52 weeks, some treated with agonists. RESULTS: Ovariectomy increased pulse wave velocity extent independent changes blood...
Premenopausal women benefit from estrogen's protective effects, including lower arterial stiffness than men of the same age. Despite role, menopausal hormone therapy showed no cardiovascular benefits in Women's Health Initiative. One theory is that response to modulated by presence pre-existing disease. Estrogen signals through nuclear estrogen receptors ERα and ERβ, membrane-bound G protein-coupled receptor (GPER). Our lab has shown GPER induces effects decreased blood pressure, protection...