A5062498500- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Transcranial Magnetic Stimulation Studies
- Genetic Neurodegenerative Diseases
- Neuroscience and Neuropharmacology Research
- Botulinum Toxin and Related Neurological Disorders
- Radiopharmaceutical Chemistry and Applications
- Advanced MRI Techniques and Applications
- Neurotransmitter Receptor Influence on Behavior
- Lanthanide and Transition Metal Complexes
- Medical Imaging Techniques and Applications
- Conducting polymers and applications
- RNA modifications and cancer
- Advanced Neuroimaging Techniques and Applications
- RNA Research and Splicing
- Animal Behavior and Reproduction
- Animal and Plant Science Education
- Cardiovascular Syncope and Autonomic Disorders
- Pharmacological Receptor Mechanisms and Effects
- Spinal Cord Injury Research
- Spinal Fractures and Fixation Techniques
- Epilepsy research and treatment
- Cholinesterase and Neurodegenerative Diseases
- Advanced Sensor and Energy Harvesting Materials
- Traumatic Brain Injury and Neurovascular Disturbances
Iranian Center for Quantum Technologies
2025
Washington University in St. Louis
2010-2024
University of Rochester
2008-2020
University of Washington
2013
University of Tennessee Health Science Center
2010
University of Cincinnati
2008
University of Iowa Hospitals and Clinics
2004
Objective We developed a novel method to map behavioral effects of deep brain stimulation (DBS) across 3‐dimensional region and assign statistical significance after stringent type I error correction. This was applied changes in Parkinson disease (PD) induced by subthalamic nucleus (STN) DBS determine whether these responses depended on anatomical location DBS. Methods Fifty‐one PD participants with STN were evaluated off medication, during unilateral clinically optimized settings. Dependent...
The basal ganglia are thought to be important in the selection of wanted and suppression unwanted motor patterns according explicit rules (i.e. response inhibition). subthalamic nucleus has been hypothesized play a particularly critical role this function. Deep brain stimulation individuals with Parkinson's disease used test hypothesis, but results have variable. Based on current knowledge anatomical organization nucleus, we propose that location contacts deep could explain variability...
Adult-onset primary torsion dystonia (PTD) may spread to multiple body parts, but the relative risk of by site onset has not been well characterized. We retrospectively identified 602 patients with PTD out 1,500 in our electronic database and extracted age at onset, family history, spread. Survival analyses were performed for groups based on hazard ratios compared across groups. Patients adult-onset blepharospasm more likely (31% past head) than those starting neck (9%), larynx (12%), or...
THAP1 encodes a transcription factor (THAP1) that harbors an atypical zinc finger domain and regulates cell proliferation. An exon 2 insertion/deletion frameshift mutation in is responsible for DYT6 dystonia Amish-Mennonites. Subsequent screening efforts familial, mainly early-onset, primary identified additional sequence variants non-Amish subjects.To examine large cohort of subjects with adult-onset THAP1.With high-resolution melting, all 3 exons were screened 1,114 dystonia, 96...
Deep brain stimulation of the subthalamic nucleus (STN DBS) improves motor symptoms in idiopathic Parkinson's disease, yet mechanism action remains unclear. Previous studies indicate that STN DBS increases regional cerebral blood flow (rCBF) immediate downstream targets but does not reveal which regions may have functional changes associated with improved manifestations. We studied 48 patients who withheld medication overnight and underwent PET scans to measure rCBF responses bilateral DBS....
Molecular imaging and clinical endpoints are frequently discordant in Parkinson disease trials, raising questions about validity of these measures to reflect severity. We compared striatal uptake for 3 positron emission tomography (PET) tracers with vitro nigral cell counts dopamine 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated monkeys.
Objective We evaluated the efficacy of potent antioxidant C 3 to salvage nigrostriatal neuronal function after 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) exposure in nonhuman primates. is a first‐in‐class functionalized water‐soluble fullerene that reduces oxygen radical species associated with neurodegeneration vitro studies. However, has not been as neuroprotective agent Parkinson model vivo. Methods Macaque fascicularis monkeys were used double‐blind, placebo‐controlled study...
<h3>Objective</h3> Deep brain stimulation (DBS) of the subthalamic nucleus (STN) improves motor function, including gait and stability, in people with Parkinson9s disease (PD) but differences DBS contact locations within STN may contribute to variability degree improvement. Based on anatomical connectivity, dorsal be preferentially involved function ventral cognitive function. <h3>Methods</h3> To determine whether affects balance more than DBS, a double blind evaluation 23 PD patients...
Deep brain stimulation of the subthalamic nucleus, as used to treat Parkinson's disease, often brings about improvement in motor function, but can have variable effects on mood. The authors give a detailed process description electrode placement, it relates unilateral and bilateral approaches exact positioning stimulation.
ABSTRACT Background Deep brain stimulation of the subthalamic nucleus is a widely used adjunctive therapy for motor symptoms Parkinson's disease, but with variable response. Predicting response remains difficult, and novel approaches may improve surgical outcomes as well understanding pathophysiological mechanisms. The objective this study was to determine whether preoperative resting‐state functional connectivity MRI predicts from deep nucleus. Methods We collected 70 participants...
Circadian rhythms are a mechanism by which species adapt to environmental variability and fundamental understanding behavior. However, we lack data standardized framework accurately assess compare temporal activity for during rapid ecological change. Through global network representing 38 countries, leveraged 8.9 million mammalian observations create library of 14,587 diel estimates 445 species. We found that less than half the species’ were in agreement with classifications from reference...
Abstract Dystonia is an involuntary movement disorder characterized by repetitive patterned or sustained muscle contractions causing twisting abnormal postures. Several lines of evidence suggest that abnormalities dopaminergic pathways contribute to the pathophysiology dystonia. In particular, dysfunction D2‐like receptors mediate function indirect pathway in basal ganglia may play a key role. We have demonstrated with positron emission tomography patients primary focal cranial hand dystonia...
Abstract PET imaging studies of the role dopamine D2 receptor family in movement and neuropsychiatric disorders are limited by use radioligands that have near‐equal affinities for D3 subtypes susceptible to competition with endogenous dopamine. By contrast, radioligand [ 18 F] N ‐methylbenperidol ([ F]NMB) has high selectivity affinity subtype (D2R) is not sensitive Although F]NMB binding levels striatum, its utility measuring D2R extrastriatal regions unknown. A composite MR‐PET image was...
Development of an effective therapy to slow the inexorable progression Parkinson disease requires a reliable, objective measurement severity. In present study, we compare presynaptic positron emission tomography (PET) tracer uptake in substantia nigra (SN) cell loss and motor impairment 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated nonhuman primates.
To test the hypothesis that there is shared regional or global functional connectivity dysfunction in a large cohort of patients with isolated focal dystonia affecting different body regions compared to control participants. In this case-control study, we obtained resting-state MRI scans (three four 7.3-minute runs) eyes closed participants (cranial [17], cervical [13], laryngeal [18], limb [10]) and age- sex-matched controls.Rigorous preprocessing for all analyses was performed minimize...
Molecular imaging of brain vesicular acetylcholine transporter provides a biomarker to explore cholinergic systems in humans. We aimed characterize the distribution of, and optimize methods quantify, transporter–specific tracer (−)-(1-(8-(2-[<sup>18</sup>F]fluoroethoxy)-3-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)-piperidin-4-yl)(4-fluorophenyl)methanone ([<sup>18</sup>F]VAT) using PET. <b>Methods:</b> Fifty-two healthy participants aged 21–97 y had PET with [<sup>18</sup>F]VAT....
Although the c.904_906delGAG mutation in Exon 5 of TOR1A typically manifests as early-onset generalized dystonia, DYT1 dystonia is genetically and clinically heterogeneous. Recently, another (c.863G>A) has been associated with some DeltaGAG carriers present late-onset focal dystonia. The aim this study was to identify mutations a large cohort subjects mainly non-generalized primary dystonia.High resolution melting (HRM) used examine entire coding sequence 1014 (422 spasmodic dysphonia, 285...
Radioligands for DAT and VMAT2 are widely used presynaptic markers assessing dopamine (DA) nerve terminals in Parkinson disease (PD). Previous vivo imaging postmortem studies suggest that these transporter sites may be regulated as the numbers of nigrostriatal neurons change pathologic conditions. To investigate this issue, we vitro quantitative autoradioradiography to measure striatal specific binding brain from 14 monkeys after unilateral internal carotid artery infusion...