A5038947978- Biochemical Acid Research Studies
- Eicosanoids and Hypertension Pharmacology
- Inflammatory mediators and NSAID effects
- Pharmacological Receptor Mechanisms and Effects
- Chemical Synthesis and Analysis
- Synthesis and Reactivity of Heterocycles
Luhansk State Medical University
2023
Purpose of the study. The aim study was to evaluate differences in morphometric parameters kidneys rats with longterm administration nonsteroidal anti-inflammatory drugs and new derivatives cyanothioacetamide assess nephrotoxicity. Materials methods. synthesized at “ChemEx” Research Laboratory were preliminarily subjected virtual bioscreening. We selected 5 heterocyclic compounds potential analgesic activity, which confirmed various pharmacological tests. To chronic effect on kidneys,...
Background. In the majority of cases, contemporary pharmacological correction mainly focuses on most effective analgesia. Therefore, search for and research into new analgesic drugs are a priority in modern pharmacology. Objective — to establish level activity eight novel heterocyclic compounds 1,4-dihydropyridine derivatives synthesized classic test orofacial trigeminal pain animal experiments. Methods. An experimental preclinical randomized trial was carried out. The experiment conducted...