A5075474713- Vitamin D Research Studies
- Cancer therapeutics and mechanisms
- Inflammasome and immune disorders
- Gout, Hyperuricemia, Uric Acid
- Synthesis and bioactivity of alkaloids
- Berberine and alkaloids research
- Microbial Metabolism and Applications
- Plant Pathogens and Fungal Diseases
- Plant Pathogens and Resistance
- Influenza Virus Research Studies
- Phytochemicals and Antioxidant Activities
- Plant Gene Expression Analysis
- Tuberculosis Research and Epidemiology
- HIV Research and Treatment
- Plant Physiology and Cultivation Studies
- Cancer Mechanisms and Therapy
- Urticaria and Related Conditions
Northwest A&F University
2021-2024
Qinghai University
2024
Abstract Cytospora canker, caused by mali, is the most destructive disease in production of apples (Malus domestica). Adding potassium (K) to apple trees can effectively control this disease. However, underlying mechanisms resistance C. mali under high-K (HK) status remain unknown. Here, we found that HK (9.30 g/kg) tissues exhibited high resistance. The was impeded when blocking K channels, leading susceptibility even conditions. We detected a suite events tissues, including upregulation...
Summary Black wolfberry ( Lycium ruthenicum Murr.) contains various bioactive metabolites represented by flavonoids, which are quite different among production regions. However, the underlying regulation mechanism of flavonoid biosynthesis governing bioactivity black remains unclear. Presently, we compared from five Multi‐omics were performed to construct network associated with fruit bioactivity. The detailed mechanisms identified using genetic and molecular methods. Typically, Qinghai (QH)...
β -Carbolines are potentially strong alkaloids with a wide range of bioactivities, and their dimers exhibit stronger antitumor activity other than the monomers. However, detailed mechanisms -carboline in inhibiting sarcoma (SARC) remain unclear. The results showed that -carboline-3-carboxylic acid Comp1 Comp2, which were synthesized our lab modified at N 9 position linked C 3 position, exhibited effective inhibition on MG-63 proliferation (IC 50 = 4.6μM). Meanwhile, large scale transcriptome...
Gouty arthritis (GA) is a common type of inflammatory arthritis. Recent studies demonstrated that 1,25-dihydroxy vitamin D3 (1,25(OH) 2 VD3) and receptor (VD-R) play protective role in acute inflammation, but interleukin-22(IL-22) promotes especially for However, our understanding the responses 1,25(OH) 2VD3 IL-22 to gout was still unclear. Presently, in-depth metabolomics, bioinformatics clinical characteristics analyses were performed elucidate pathogenesis valuable indicators gouty...
Abstract The lipid composition performs important functions in interaction between macropha-ge and Mycobacterium tuberculosis (MTB)/Mycobacterium bovis (MB). Current understanding regarding the responses of bovine alveolar macrophage (BAM) to MTB/MB is quite limiting. present study conducted lipidomics transcriptome assess alterations BAM compositions upon MB MTB infection. We found that both induced glycerophospholipids accumulation BAM, more composition. could affect contents various...