A5070643664- Cancer Research and Treatments
- Metabolism and Genetic Disorders
- Neuroscience and Neuropharmacology Research
- Cancer, Hypoxia, and Metabolism
- Receptor Mechanisms and Signaling
- Peptidase Inhibition and Analysis
- Cancer-related gene regulation
- Neurotransmitter Receptor Influence on Behavior
- Amino Acid Enzymes and Metabolism
- Phytochemical Studies and Bioactivities
- HER2/EGFR in Cancer Research
- Remote Sensing and Land Use
- Phytochemistry and Biological Activities
- Chemical Synthesis and Analysis
- Mast cells and histamine
- Ion channel regulation and function
- Nicotinic Acetylcholine Receptors Study
- Berberine and alkaloids research
- Sesquiterpenes and Asteraceae Studies
- Natural product bioactivities and synthesis
- Lung Cancer Treatments and Mutations
- Memory and Neural Mechanisms
- Biological Activity of Diterpenoids and Biflavonoids
- Protein Kinase Regulation and GTPase Signaling
- Molecular Sensors and Ion Detection
University of Chinese Academy of Sciences
2024
Shanghai Institute of Materia Medica
2024
Sun Yat-sen University
2013
Kyoto Prefectural University of Medicine
1995-1998
The urea cycle is frequently rewired in cancer cells to meet the metabolic demands of cancer. Elucidation underlying mechanism by which oncogenic signaling mediates reprogramming could help identify targetable vulnerabilities. In this study, we discovered that activation KRAS non-small cell lung (NSCLC) silenced expression argininosuccinate synthase 1 (ASS1), a enzyme catalyzes production arginine from aspartate and citrulline, thereby diverted utilization pyrimidine synthesis high demand...
Some natural alkaloids from medicinal plants, such as yohimbine and its derivatives, have been reported with adrenoceptor (AR) α 2 subtypes inhibiting activity. In trying to address the possible mechanism of action, a set homology models AR was built based on MOE. After that, docking molecular dynamics methods were used investigate binding modes derivatives in active pocket subtype A, B, C. The key interactions between 3 ligands receptors mapped. Binding mode analysis presents strong...
To study the chemical constituents from rhizome of Paris axialis.The compounds were isolated by column chromatography with silica gel and purified Sephadex LH-20 preparative RP-HPLC. The structures identified means spectroscopic methods.Fourteen EtOAc extract n-BuOH P. axialis. Their as daucosterol (1), stigmasterol-3-O-beta-D-glycopyranoside (2), beta-ecdysterone (3), pennogenin-3-O-alpha-L-arabinofuranosyl (1 --> 4) -[alpha-L -rhamnopyranosyl 2)] -beta-D-glycopyranoside (4),...
<p>Differential gene expression of BEAS-2B cells expressing KRAS-G12D or empty vector control</p>
<p>Supplementary figure S1-5</p>
<div>Abstract<p>The urea cycle is frequently rewired in cancer cells to meet the metabolic demands of cancer. Elucidation underlying mechanism by which oncogenic signaling mediates reprogramming could help identify targetable vulnerabilities. In this study, we discovered that activation KRAS non–small cell lung (NSCLC) silenced expression argininosuccinate synthase 1 (ASS1), a enzyme catalyzes production arginine from aspartate and citrulline, thereby diverted utilization...
<div>Abstract<p>The urea cycle is frequently rewired in cancer cells to meet the metabolic demands of cancer. Elucidation underlying mechanism by which oncogenic signaling mediates reprogramming could help identify targetable vulnerabilities. In this study, we discovered that activation KRAS non–small cell lung (NSCLC) silenced expression argininosuccinate synthase 1 (ASS1), a enzyme catalyzes production arginine from aspartate and citrulline, thereby diverted utilization...
<p>Differential gene expression of BEAS-2B cells expressing KRAS-G12D or empty vector control</p>
<p>Supplementary figure S1-5</p>