A5049052893- CAR-T cell therapy research
- Phagocytosis and Immune Regulation
- Chronic Lymphocytic Leukemia Research
- Cancer Cells and Metastasis
- Hematopoietic Stem Cell Transplantation
- Extracellular vesicles in disease
- Digestive system and related health
- Infant Nutrition and Health
- Renal Transplantation Outcomes and Treatments
- Epigenetics and DNA Methylation
- Hedgehog Signaling Pathway Studies
- Neonatal Respiratory Health Research
- TGF-β signaling in diseases
- Genetic Syndromes and Imprinting
- Oral and Maxillofacial Pathology
- Biomedical Ethics and Regulation
- Oral and gingival health research
- T-cell and B-cell Immunology
- Metastasis and carcinoma case studies
- Immune Cell Function and Interaction
- Acute Myeloid Leukemia Research
- Bone health and treatments
- Bone and Dental Protein Studies
- Fibroblast Growth Factor Research
- Nursing Education, Practice, and Leadership
Mayo Clinic
2018-2023
Mayo Clinic in Arizona
2017-2020
University of Minnesota
2011-2017
University of Minnesota Medical Center
2012
University of Minnesota System
2011-2012
Chimeric antigen receptor (CAR) T cell therapy has yielded unprecedented outcomes in some patients with hematological malignancies; however, inhibition by the tumor microenvironment prevented broader success of CART therapy. We used chronic lymphocytic leukemia (CLL) as a model to investigate interactions between and cells. CLL is characterized an immunosuppressive microenvironment, abundance systemic extracellular vesicles (EVs), relatively lower durable response rate In this study, we...
Fibroblast growth factors (FGFs) and their receptors (FGFRs) have been implicated in promoting breast cancer progression. While the autocrine effects of FGFR activation tumor cells extensively studied, little is known about cell-derived FGFs on microenvironment. Because FGF signaling has regulation bone formation osteoclast differentiation, we hypothesized that are capable modulating function contributing to metastatic lesions bone. Initial studies examining expression during differentiation...
To assess the expression of Twisted gastrulation (TWSG1) protein, which regulates activity bone morphogenetic proteins (BMPs) in extracellular space malignant epithelial tumours liver.Thirteen hepatocellular carcinoma (HCC) samples and 12 intrahepatic cholangiocellular (CCA) were compiled into diagnosis-specific tissue microarrays. Sections immunostained with a monoclonal antibody against TWSG1 polyclonal BMP4. Human cell lines also used, including one HCC line (HepG2), three CCA (OZ,...
The receptor tyrosine kinase AXL is a member of the TYRO3, AXL, and proto-oncogene tyrosine-protein MER family plays pleiotropic roles in cancer progression. expressed immunosuppressive cells, which contributes to decreased efficacy immunotherapy. Therefore, we hypothesized that inhibition could serve as strategy overcome resistance chimeric antigen T (CAR T)-cell therapy. To test this, determined impact on CD19-targeted CAR (CART19)-cell functions. Our results demonstrate cells express high...
Twisted Gastrulation (TWSG1) is a conserved, secreted glycoprotein that modulates signaling of bone morphogenetic proteins (BMPs) in the extracellular space. Deletion exon 4 mouse Twsg1 (mTwsg1) associated with significant craniofacial defects. However, little understood about biochemical properties corresponding region protein. We have uncovered role for sequences as encoding only two glycosylation sites mTWSG1 entire or mutation both within abolishes mTWSG1. Importantly, we find constructs...
Chimeric antigen receptor T-cell therapy (CART) is limited by the development of cytokine release syndrome (CRS) and neurotoxicity (NT). CRS related to extreme elevation cytokines massive T cell expansion. Preliminary studies suggest that NT might be mediated myeloid cells cross blood brain barrier. This supported correlative analysis from CART19 pivotal trials where CD14+ numbers were increased in cerebrospinal fluid patients developed severe (Locke et al, ASH 2017). Thus, we aimed...
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<div>Abstract<p>The receptor tyrosine kinase AXL is a member of the TAM (Tyro3, AXL, and proto-oncogene tyrosine-protein Mer) family plays pleiotropic roles in cancer progression. expressed immunosuppressive cells, which contributes to decreased efficacy immunotherapy. Therefore, we hypothesized that inhibition could serve as strategy overcome resistance chimeric antigen T (CART)-cell therapy. To test this, determined impact on CD19-targeted CART (CART19)-cell functions. Our...
<p>Supplementary Figure Legends</p>
<p>Supplementary Figure Legends</p>
<p>Supplementary Figures S1-S17</p>
CLINICAL CASE STUDY article Front. Physiol., 06 December 2012Sec. Craniofacial Biology and Dental Research https://doi.org/10.3389/fphys.2012.00458
Background: Acute Graft Versus Host Disease (GVHD) is caused by the recognition of recipient antigens donor T lymphocytes following allogeneic stem cell transplant (SCT). The development clinical and histo-pathological changes similar to GVHD after autologous SCT (ASCT) a poorly understood controversial phenomenon. We aimed analyze: 1) outcomes correlatives for in ASCT recipients 2) baseline NK functions patients that developed ASCT, compared matched controls. Methods: Retrospective analysis...