A5101792025- Composite Structure Analysis and Optimization
- Structural Analysis and Optimization
- Structural Load-Bearing Analysis
- Vibration and Dynamic Analysis
- Nonlocal and gradient elasticity in micro/nano structures
- Dynamics and Control of Mechanical Systems
- Immunotherapy and Immune Responses
- Fluid Dynamics Simulations and Interactions
- Immune Response and Inflammation
- Peripheral Neuropathies and Disorders
- T-cell and B-cell Immunology
- Research on Leishmaniasis Studies
- Parasites and Host Interactions
- Aeroelasticity and Vibration Control
- Railway Engineering and Dynamics
- Land Use and Ecosystem Services
- Toxin Mechanisms and Immunotoxins
- Immune Cell Function and Interaction
- Numerical methods in engineering
- Monoclonal and Polyclonal Antibodies Research
- Myasthenia Gravis and Thymoma
- Advanced Materials and Mechanics
- Urban Heat Island Mitigation
- Escherichia coli research studies
- Multiple Sclerosis Research Studies
Northwest A&F University
2025
Dalian University of Technology
2014-2024
Zhejiang Sci-Tech University
2024
Harbin Medical University
1992-2024
Second Affiliated Hospital of Harbin Medical University
2024
North China University of Water Resources and Electric Power
2021
Shandong University of Technology
2021
Qingdao University of Science and Technology
2021
Shandong University of Science and Technology
2019
Beijing University of Posts and Telecommunications
2019
Oral administration of antigens, including allergens and autoantigens, may be an efficient way to prevent diseases associated with untoward immune responses self- non-self-antigens. However, this approach has met limitations because it usually requires repeated administrations large doses antigen is less in already host, the effect short duration. We report that a single oral minute amounts particulate or soluble coupled B subunit cholera toxin (CTB) can markedly suppress systemic naive...
Abstract The pathogenesis of multiple sclerosis (MS) could involve an autoimmune response to proteolipid protein (PLP). Immunization experimental animals with this major myelin can lead allergic encephalomyelitis. To identify a possible role PLP as target antigen in MS, we evaluated T celi immunity blood and cerebrospinal fluid (CSF) from patients MS controls by counting cells which short‐term cultures secreted interferon‐γ. PLP‐specific B cell was analyzed secreting anti‐PLP antibodies....
Oral administration of autoantigens can prevent and partially suppress autoimmune diseases in a number experimental models, Depending on the dose antigen fed, this approach appears to involve distinct yet reversible short-lasting mechanisms (anergy/deletion suppression) usually requires repeated feeding large (suppression) massive (anergy/deletion) amounts be effective. Most importantly, is relatively less effective animals already systemically sensitized fed antigen, such as harboring...
Abstract Myelin basic protein (MBP)‐autoreactive T cells have a crucial pathogenetic role in experimental allergic encephalomyelitis (EAE) and certain MBP epitopes may be immunodominantly recognized. The heterogeneity quantity of the cell response to different multiple sclerosis (MS) non‐MS controls is not so clearly defined. We now study reactivity six peptides MS compared short‐term cultures blood mononuclear by measuring numbers that secrete interferon‐γ antigen. In comparison with...
Urban parks have been proven to cool the surrounding environment, and can thus mitigate urban heat island an extent by forming a park cooling island. However, comprehensive understanding of mechanism islands is still required. Therefore, we studied 32 in Jinan, China proposed absolute relative indicators depict detailed features High-spatial-resolution GF-2 images were used obtain land cover parks, Landsat 8 TIR examine thermal environment applying buffer analysis. Linear statistical models...
Myasthenia gravis (MG) is strongly associated with antibodies to acetylcholine receptor (AChR), whereas the extent of T cell involvement not settled. The number cells secreting interferon-gamma (IFN-gamma) in response AChR during 48 h culture blood mononuclear (PBL) may reflect AChR-reactive cells. Using an immunospot assay, we detected such 23 30 patients MG at a mean 1 per 33.333 PBL. were also found other neurological diseases (OND) and healthy subjects but lower frequencies numbers....
Abstract The enzyme‐linked immunospot (ELISPOT) assay has been proven to be an efficient and sensitive method for the enumeration of single cells secreting antibodies or cytokines. Here we have used this determine number interleukin‐4 (IL‐4)‐ interferon‐γ (IFN‐γ)‐producing in vitro secondary responses tetanus toxoid (TT) mycobacterial antigen (purified protein derivative; PPD) mitogen phytohemagglutinin (PHA). PHA‐induced IL‐4 IFN‐γ secretion was well correlated suggesting polyclonal...
This article focuses on analytical solutions for bifurcation buckling of FGM cylindrical shells under thermal and compressive loads. A new solution methodology is established based Hamilton's principle. The fundamental problem subsequently transformed into the symplectic eigenvalues eigenvectors, respectively. Then, by applying a unidirectional Galerkin method, imperfection sensitivity an imperfect shell discussed in detail. reveal that boundary conditions, volume fraction exponent,...
Based on Hamilton's principle, a new accurate solution methodology is developed to study the torsional bifurcation buckling of functionally graded cylindrical shells in thermal environment. The effective properties materials (FGMs) are assumed be functions ambient temperature as well thickness coordinate shell. By applying Donnell's shell theory, lower-order Hamiltonian canonical equations established, from which eigenvalues and eigenvectors solved critical loads modes concern, respectively....
Exact solutions for the torsional bifurcation buckling of functionally graded (FG) multilayer graphene platelet reinforced composite (GPLRC) cylindrical shells are obtained. Five types platelets (GPLs) distributions considered, and a slope factor is introduced to adjust distribution profile GPLs. Within framework Donnell’s shell theory with aid symplectic mathematics, set lower-order Hamiltonian canonical equations established solved analytically. Consequently, critical loads corresponding...