A5102951878- Cancer, Lipids, and Metabolism
- CRISPR and Genetic Engineering
- Plant Virus Research Studies
- Estrogen and related hormone effects
- Protein Degradation and Inhibitors
- Ubiquitin and proteasome pathways
- Prostate Cancer Treatment and Research
- Insect symbiosis and bacterial influences
- Microtubule and mitosis dynamics
University of Minnesota
2024
University of Minnesota Medical Center
2024
Glioblastoma is the most common primary malignant brain tumor of adults and one lethal all cancers. Patients with this disease have a median survival 15 months from time diagnosis despite surgery, radiation, chemotherapy. New treatment approaches are needed. Recent works suggest that glioblastoma patients may benefit molecularly targeted therapies. Here, we address compelling need for identification new molecular targets. Leveraging global gene expression data two independent sets clinical...
Realizing the full potential of genome editing for crop improvement has been slow due to inefficient methods reagent delivery and reliance on tissue culture creating gene-edited plants. RNA viral vectors offer an alternative approach delivering gene engineering reagents bypassing requirement. Viruses, however, are often excluded from shoot apical meristem, making virus-mediated in some species. Here, we developed effective approaches generating shoots Cas9-expressing transgenic tomato plants...
Androgen receptor (AR) drives prostate cancer (PC) growth and progression, targeting AR signaling is the mainstay of pharmacological therapies for PC. Resistance develops relatively fast as a result refueled activity. A major gap in field lack understanding targetable mechanisms that induce persistent expression castrate-resistant PC (CRPC). This study uncovers an unexpected function active Stat5 signaling, known promoter clinical potent inducer gene transcription. suppression inhibited...