Serum homocysteine (Hcy) is considered to be a reliable biomarker of cardiovascular, cerebrovascular and neurological diseases. Therefore, rapid, specific sensitive measurement crucial for prevention diagnosis. Electrochemical methods, which benefit from simplicity, low-cost quick response, have been widely utilized in the determination targeted biomolecules. In this work, based upon portable mini-potentiostat, electrochemical biosensor has successfully developed combined with modification...

Aiming at improving the speed and accuracy of auto-focus for telescope observation, algorithms image estimation were investigated are discussed in this article. Based on quality assessment, auto-focusing process system is realized by using mountain-climb search method. Several evaluation functions tested different scenarios. It demonstrated that Tenengrad function (IEF) suitable an instant accurate telescope. Furthermore, we implemented sampling dynamic adaptive focusing window (ES-DAFW)...

Introduction Continuous cropping challenges have gradually emerged as pivotal factors limiting the sustainable development of agricultural production. Allelopathicals are considered to be primary obstacles. However, there is limited information on allelopathic accumulation across various continuous years and its correlation with associated challenges. Methods Tobacco was subjected varying planting durations: 1 year (CR), 5 (CC5), 10 (CC10), 15 (CC15). Results Our findings unveiled...

Employing hypoxia-activated prodrugs is an appealing oncotherapy strategy, but limited by insufficient tumor hypoxia. Moreover, a standalone prodrug fails to treat tumors satisfactorily due complexity. Herein, nanosystem (TPZ@FeMSN-GOX) was established for triple synergetic cancer starvation therapy, chemotherapy and chemodynamic therapy (CDT). TPZ@FeMSN-GOX prepared synthesizing iron-doped mesoporous silica nanoparticles (FeMSNs) followed surface conjugation with glucose oxidase (GOX), then...

Poor tumor penetration is a major obstacle to nanomedicine for achieving effective anticancer therapy. Tumor microenvironment-induced size shrinkage promising strategy overcome the drug barrier across dense matrix. Herein, we design size-shrinkable nanocarrier that uses acid as means of triggering change in particle co-achievement efficient accumulation followed by deep and rapid clearance from body. This constructed pH-sensitive lipid layer shell an ultrasmall amino-functionalized...

In this paper, a bilateral prediction and intersection calculation autofocus method for automated microscopy, which obtains the in-focus position by calculating of predicted left right focus measure curves located respectively in sides peak curve, is proposed performed. According to method, area including curve its neighbourhoods should be determined firstly, are considered as sampling areas. The appropriate predicting models according two sample sequences, comprise values evaluating sampled...

This paper presents an effective approach for rock mass discontinuity extraction based on the terrestrial LiDAR scanning 3-D point clouds. First, a Quadtree-Octree index method that retained adjacency relationship of clouds was proposed to organize cloud data in high-efficiency manner. Second, normal vector (NV) calculation directly conducted by local triangulated irregular networks together with eight neighborhood areas. Third, double-clustering strategy developed and NV discussed Step one...

Long term monocropping is considered to change soil chemical properties and affect the yield. It significant study relationship among character, rhizosphere microorganism crop yield under long monocropping, clarify mechanism of obstacle. In this work, a continuous cropping area tobacco in Southwest China was selected, which Nicotiana tabacum cv. Yunyan87 planted. The disease incidence, yield, properties, allelochemicals microbial community were determined mature phase with treatments for 2...

Mitochondria-targeted copper-depletion is emerging as an attractive strategy to combat cancer. However, existing copper molecular chelators are non-specific, toxic and ineffective. Here, it reported that multifunctional nanoparticles (MSN-TPP/BNA-DPA) can not only target mitochondria deprive ions trigger therapy, but also serve nanocarriers deliver anticancer drugs for chemotherapy, which engineered by conjugating a fluorophore 4-bromo-1,8-naphthalicanhydride (BNA), copper-depriving moiety...

A nanoplatform with functions of the Fenton-reaction, self-supplied H 2 O , GSH-elimination, S generation and DOX delivery for synergistic multi-enhanced CDT/chemotherapy/H cancer therapy.

In order to obtain a larger torque for permanent magnet spherical motor, the method of optimizing structural parameters motor is studied. Based on premise volume minimization, this paper proposes set nonlinear data fitting by BP neural network, using genetic algorithm and particle swarm calculate maximum corresponding parameters. According sample torque, network trained fit space, then optimal are found in combination with network. Due its accuracy feasibility, finite element analysis used...

Quaternary compound Cu 2 ZnSnSe 4 (CZTSe) is one of the most promising absorber layer materials for thin film solar cells. In present work, CZTSe nanocrystals were successfully synthesized via pot route, and influences reaction temperature on structural, compositional, morphological optical properties as‐synthesized investigated in detail X‐ray powder diffraction (XRD), energy dispersive spectrometry (EDS), transmission electron microscopy (TEM) UV‐Vis spectrophotometry, respectively. The...

Ca2+ overload has attracted an increasing attention due to its benefit of precise cancer therapy, but efficacy is limited by the strong excretion cells. Moreover, monotherapy usually fails treat tumors satisfactorily. Herein, we develop a multifunctional nanosystem that could induce multipathway and simultaneously produce chemotherapy for synergistic tumor therapy. The (CaMSN@CUR) prepared synthesizing Ca-doped mesoporous silica nanoparticle (CaMSN) followed loading anticancer drug curcumin...

This paper proposes a method of injected alternating current-field measurement (IAC-FM) for detecting orthogonal cracks in the piston rod hydraulic cylinder gate hoist. Using this method, both longitudinal and transverse can be detected at same time. An magnetic field is produced inside steel by axially injecting an current into rod. The crack perturbs circumferential field, whereas axial direction. Analyses behaviors vicinity were proposed, using three-dimensional finite element software....

Dam deformation monitoring is a critical technical measure to ensure the safe and stable operation of dams. It involves measuring structural response engineering dams using instruments or technological means. By analyzing regularity trend data, potential safety anomalies can be forecasted warned against, providing timely reliable data for formulation implementation risk removal measures. Horizontal displacement, as most intuitive effective reflection dam's state under action internal...

Arsenic (As) is a highly toxic carcinogen. Its pollution spreads to soil and water, posing threat the global environment, crop production food safety. In this study, explore recovery potential of different aquatic plants As polluted three submerged Hydrilla verticillata L., Ceratophyllum demersum Potamogeton malaianus M. were took as material, absorption accumulation arsenic was investigated. The experimental grown in standard Hoagland solution containing 3 form As: As(V), dimethylarsinic...