A5082318375- Plant Reproductive Biology
- Plant Molecular Biology Research
- RNA and protein synthesis mechanisms
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Chromosomal and Genetic Variations
- Plant Genetic and Mutation Studies
- RNA regulation and disease
- interferon and immune responses
- RNA Research and Splicing
Oklahoma State University
2020-2023
As a defense strategy against viruses or competitors, some microbes use anticodon nucleases (ACNases) to deplete essential tRNAs, effectively halting global protein synthesis. However, this mechanism has not been observed in multicellular eukaryotes. Here, we report that human SAMD9 is an ACNase specifically cleaves phenylalanine tRNA (tRNA
Significance SAMD9 and SAMD9L (SAMD9/9L) are important innate immune defenders against viruses the development of myeloid tumors. They form a crucial host barrier that poxviruses must overcome for successful infection. A myriad human diseases including many pediatric myelodysplastic syndromes caused by mutations in SAMD9/9L. However, molecular functions SAMD9/9L how their executed unknown, hindering progress developing effective therapies SAMD9/9L-associated diseases. Here, we identified...
Homeobox transcription factors are key regulators of morphogenesis and development in both animals plants. In plants, the WUSCHEL-related homeobox (WOX) family function as central organizers several developmental programs ranging from embryo patterning to meristematic stem-cell maintenance through transcriptional activation repression mechanisms. The Medicago truncatula STENOFOLIA ( STF ) gene is a master regulator leaf-blade lateral development. Here, crystal structure homeodomain (HD)...
Abstract Homeobox transcription factors are key regulators of morphogenesis and development in both animals plants 1 . In plants, the WUSCHEL-related homeobox (WOX) family function as central organizers several developmental programs from embryo patterning to meristematic stem cell maintenance through transcriptional activation repression 2-4 The structure WOX Homeodomain (HD) molecular mechanism its interaction with DNA unknown. Here, we report 2.1 Å crystal STENOFOLIA (STF) HD Medicago...