A5057541000- Monoclonal and Polyclonal Antibodies Research
- Hepatitis C virus research
- CAR-T cell therapy research
- SARS-CoV-2 detection and testing
- Animal Virus Infections Studies
- vaccines and immunoinformatics approaches
- SARS-CoV-2 and COVID-19 Research
- Influenza Virus Research Studies
- Systemic Lupus Erythematosus Research
- Distributed and Parallel Computing Systems
- HIV Research and Treatment
- Scientific Computing and Data Management
Advanced Bioscience Laboratories (United States)
2024
University of Maryland, College Park
2024
University of Maryland, Baltimore
2024
National Institute of Standards and Technology
2024
Institute for Bioscience and Biotechnology Research
2024
Research Institute for Bioscience and Biotechnology
2024
New Horizons Diagnostics (United States)
2022-2023
Hepatitis C virus (HCV) is a major medical health burden and the leading cause of chronic liver disease cancer worldwide. More than 58 million people are chronically infected with HCV, 1.5 new infections occurring each year. An effective HCV vaccine public need as recognized by World Health Organization. However, due to high variability its ability escape immune response, rapidly accumulates mutations, making development formidable challenge. must elicit broadly neutralizing antibodies...
Hepatitis C virus (HCV) is a major medical health burden and leading cause of chronic liver disease cancer worldwide. More than 58 million people are chronically infected with HCV, 1.5 new infections occurring each year. An effective HCV vaccine public need as recognized by the World Health Organization. However, due to high variability its ability escape immune response, rapidly accumulates mutations making formidable challenge. must elicit broadly neutralizing antibodies (bnAbs) in...
Deep learning methods, trained on the increasing set of available protein 3D structures and sequences, have substantially impacted modeling design field. These advancements facilitated creation novel proteins, or optimization existing ones designed for specific functions, such as binding a target protein. Despite demonstrated potential approaches in designing general binders, their application immunotherapeutics remains relatively underexplored. A relevant is T cell receptors (TCRs). Given...
Previous studies have attempted to characterize the antibody response of individuals SARS-CoV-2 virus on a linear peptide level by utilizing microarrays. These helped identify epitopes that potential be used for diagnostic tests infected individuals. The immunological responses who received two most popular vaccines available in US, Moderna mRNA-1273 or Pfizer BNT162b2 mRNA vaccines, not been characterized. We aimed peptides spike protein elicited high IgG IgA binding activity and compare...
Deep learning methods, trained on the increasing set of available protein 3D structures and sequences, have substantially impacted modeling design field. These advancements facilitated creation novel proteins, or optimization existing ones designed for specific functions, such as binding a target protein. Despite demonstrated potential approaches in designing general binders, their application immunotherapeutics remains relatively unexplored. A relevant is T cell receptors (TCRs). Given...
Abstract The ability to control protein conformations and dynamics through structure-based design has been useful in various scenarios, including engineering of viral antigens for vaccines. One effective strategy is the substitution residues proline amino acids, which due its unique cyclic side chain can favor rigidify key backbone conformations. To provide community with a means readily identify explore designs target proteins interest, we developed Proscan web server. provides assessment...
ABSTRACT Previous studies have attempted to characterize the antibody response of individuals SARS-CoV-2 virus on a linear peptide level by utilizing microarrays. These helped identify epitopes that potential be used for diagnostic tests infected individuals, however, immunological responses who received currently available Moderna mRNA-1273 or Pfizer BNT162b2 mRNA vaccines not been characterized. We aimed peptides spike protein elicited high IgG IgA binding activity and compare...