A5047818661- Advanced Biosensing Techniques and Applications
- Biosensors and Analytical Detection
- 3D Printing in Biomedical Research
- Advanced biosensing and bioanalysis techniques
- Cell Image Analysis Techniques
- Advanced Fluorescence Microscopy Techniques
- Microfluidic and Bio-sensing Technologies
- Ultrasound and Cavitation Phenomena
- Ultrasound and Hyperthermia Applications
- Advanced Sensor and Energy Harvesting Materials
- Wound Healing and Treatments
- Dielectric materials and actuators
- Microfluidic and Capillary Electrophoresis Applications
- Photoacoustic and Ultrasonic Imaging
- Advanced Chemical Sensor Technologies
- Cancer Cells and Metastasis
- Cancer-related gene regulation
- Cellular Mechanics and Interactions
- TGF-β signaling in diseases
- Cell Adhesion Molecules Research
École Polytechnique Fédérale de Lausanne
2022-2025
University of Tehran
2017-2019
Methods for the analysis of cell secretions at single-cell level only provide semiquantitative endpoint readouts. Here we describe a microwell array real-time spatiotemporal monitoring extracellular from hundreds single cells in parallel. The incorporates gold substrate with arrays nanometric holes functionalized receptors specific analyte, and is illuminated light spectrally overlapping device's spectrum extraordinary optical transmission. Spectral shifts surface plasmon resonance resulting...
Organoid tumor models have emerged as a powerful tool in the fields of biology and medicine such 3D structures grown from cells recapitulate better characteristics, making these tumoroids unique for personalized cancer research. Assessment their functional behavior, particularly protein secretion, is significant importance to provide comprehensive insights. Here, label-free spectroscopic imaging platform presented with advanced integrated optofluidic nanoplasmonic biosensor that enables...
Current imaging technologies are limited in their capability to simultaneously capture intracellular and extracellular dynamics a spatially temporally resolved manner. This study presents multimodal system that integrates nanoplasmonic sensing with multichannel fluorescence concomitantly analyze processes space time at the single-cell level. Utilizing highly sensitive gold nanohole array biosensor, provides label-free real-time monitoring of secretion, while implementing...
Abstract The demand for continuous monitoring of biochemical markers diagnostic purposes is increasing as it overcomes the limitations traditional intermittent measurements. This study introduces a method long‐term, plasmonic biosensing oligonucleotides with high temporal resolution. Our based on regeneration‐based reversibility approach that ensures rapid in less than 1 minute, allowing sensor to fully reset after each measurement. We investigated label‐free and AuNP enhancements different...
Detecting the micrometastasis is a major challenge in patients' survival. The small volume of biopsied tissue results limited number histopathological samples and might reduce rate accurate diagnosis even by molecular technologies. We introduce microelectronic biochip (named Metas-Chip) to detect unprocessed liquid or solid samples. It works based on tendency malignant cells track single human umbilical vein endothelial cell (HUVEC)-sensing traps. Such detach themselves from sample invade...
Artificial cavitation as a prerequisite of sonoporation, plays an important role on the ultrasound (US) assisted drug delivery systems. In this study, we have proposed new method microbubble (MB) generation by local electrolysis medium. An integrated interdigital array three-electrode system was designed and patterned nickel-coated quartz substrate then, short DC electrical pulse applied that consequently resulted in distributed microbubbles at periphery electrodes. Growth carbon nanotube...
The Activin-A precursor dimer can be cleaved by furin, but how this proteolytic maturation is regulated in vivo and it facilitates access to signaling receptors unclear. Here, analysis a syngeneic melanoma grafting model shows that without furin coexpression, failed accelerate tumor growth, correlating with failure of one or both subunits undergo cleavage signal-sending cells, even though compensatory processing host cells nonetheless sustained elevated circulating levels. In reporter...
Elastomers are flexible polymers with low young's modulus and high failure strain. VHB, considered as an acrylic elastomer, is widely used in smart materials due to its dielectric electromechanical actuating properties. To the best of our knowledge, this polymer has not been applied cell culture stretching substrate role played by PDMS. Herein, we present structural properties VHB vs. PDMS then prove safety using different viability assays. Moreover, analyzed effect on cultured cells.
It is increasingly being accepted that cells' physiological functions are substantially dependent on the mechanical characteristics of their surrounding tissue. This mainly due to key role biomechanical forces cells and nucleus' shapes, which have capacity regulate chromatin conformation thus gene regulations. Therefore, it reasonable postulate altering properties tissue may change cell functions. Here, stretching (as a model variations) probed in migration invasion using human normal...
Abstract The demand for continuous monitoring of biochemical markers diagnostic purposes is increasing as it overcomes the limitations traditional intermittent measurements. This study introduces a method long‐term, plasmonic biosensing oligonucleotides with high temporal resolution. Our based on regeneration‐based reversibility approach that ensures rapid in less than 1 minute, allowing sensor to fully reset after each measurement. We investigated label‐free and AuNP enhancements different...
In article number 1800294, Mohammad Abdolahad and co-workers report the role of cell stretching (as a model biomechanical variations) in migration invasion capacity using human normal cancerous breast cells. Several analyses indicate that cell-stretching process could increase capabilities cells, respectively.
We report a high-throughput biosensing microarray platform integrating ultrasensitive nanoplasmonic substrate and microwell compartments for label-free real-time secretome monitoring. Interleukin-2 from hundreds of single EL4 cells were measured statistical analysis was done.