A5027425489- Synthesis and biological activity
- Multicomponent Synthesis of Heterocycles
- Bioactive Compounds and Antitumor Agents
- Cancer therapeutics and mechanisms
- Quinazolinone synthesis and applications
- Ionic liquids properties and applications
- Synthesis and Biological Evaluation
- Synthesis and bioactivity of alkaloids
- Antibiotic Resistance in Bacteria
- Pharmaceutical and Antibiotic Environmental Impacts
- Organoselenium and organotellurium chemistry
- Chemical Synthesis and Reactions
- Synthesis of Indole Derivatives
- Antibiotics Pharmacokinetics and Efficacy
- Biochemical and Molecular Research
- Free Radicals and Antioxidants
- Synthesis of heterocyclic compounds
- Synthesis and Reactions of Organic Compounds
- Selenium in Biological Systems
- Synthesis and Characterization of Heterocyclic Compounds
Cairo University
2018-2025
In this work, a novel, green, and atom-efficient method for the synthesis of tetrahydro-β-carboline derivatives using electrochemistry (EC) in deep eutectic solvents (DESs) was reported. The EC reaction conditions were optimized to achieve highest yield. experimental design also perform two-step, one-pot reaction, thereby time, workup procedure, needed all reduced. new approach achieved our strategy as served decrease time eliminate use hazardous catalysts, lower energy required targeted...
Abstract β‐Carboline ring is widely distributed in nature and several β ‐carboline alkaloids were extracted from marine creatures, bacteria, fungi, food stuffs, plants, mammals. Synthetic ‐carbolines derivatives reported to exhibit various biological activities. This review highlighted the recent progress achieved last decade Pictet‐Spengler synthesis of with a special focus on green methods catalysts used for synthesis.
Ciprofloxacin (CIP) and levofloxacin (LEV), widely used fluoroquinolone antibiotics, are often found in sewage from the treatment plants marine environment. In this study, CIP LEV biodegrading bacterial consortia were obtained industrial wastewater. Microorganisms these identified as Acinetobacter baumannii (A. baumannii), Klebsiella pneumoniae (K. pneumoniae) Elizabethkingia miricola (E. miricola). The impacts of critical operating parameters on elimination by have been investigated...
Abstract Our main goal was to design and synthesize novel lomefloxacin derivatives that inhibit the topoisomerase II enzyme, leading potent anticancer activity. Lomefloxacin substituted at position 3 7 were synthesized screened for cytotoxic activity utilizing 60 different human cancer cell lines. Furthermore, compounds 3a,b,c,e revealed broad-spectrum (with mean percent GI more than 47%) further evaluated using five dose concentrations calculating 50 . Compound 3e then cycle analysis...
Abstract In this study, a new green method was developed for the synthesis of bis(indolyl)methane derivatives using electrochemical bisarylation reaction in deep eutectic solvents as alternative to traditional and electrolytes. The effects varying time, current, type solvent material electrodes were all studied. optimum conditions involved use ethylene glycol/choline chloride with ratio 2:1 at 80 °C 45 min. Graphite platinum used cathode anode, respectively. newly offered many advantages...
4-Substitutedaminoquinazoline scaffolds were reported to possess potent cytotoxic and EGFR inhibitory activity such as gefitinib (Iressa), erlotinib (Tarceva) tandutinib.Synthesis of novel 4-substitutedaminothieno[2,3-d]pyrimidine derivatives bioisosters 4-substitutedaminoquinazoline with potential activity.Novel 4a-i 5a-c synthesized via reacting corresponding 4-chlorothieno[2,3-d]pyrimidine 3a-c N-methylpiperazine, morpholine, N-phenylpiperazine or 1,3-propanediamine. Six compounds (2a,...