A5047128950- Osteoarthritis Treatment and Mechanisms
- Temporomandibular Joint Disorders
- Lower Extremity Biomechanics and Pathologies
- Tissue Engineering and Regenerative Medicine
- Obstructive Sleep Apnea Research
- Biomedical and Engineering Education
- Electrospun Nanofibers in Biomedical Applications
- Science, Research, and Medicine
- Spine and Intervertebral Disc Pathology
- Veterinary Equine Medical Research
- Diabetic Foot Ulcer Assessment and Management
- Musculoskeletal pain and rehabilitation
- Total Knee Arthroplasty Outcomes
- Botulinum Toxin and Related Neurological Disorders
- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Health Systems, Economic Evaluations, Quality of Life
- Quality and Safety in Healthcare
- Muscle activation and electromyography studies
- Tribology and Lubrication Engineering
- Climate Change Communication and Perception
- Periodontal Regeneration and Treatments
- Infectious Aortic and Vascular Conditions
- Silk-based biomaterials and applications
- Discourse Analysis in Language Studies
Clemson University
2008-2023
United States Food and Drug Administration
2018-2021
Cornell University
2018
A custom-designed three-dimensional additive manufacturing device was developed to fabricate scaffolds for intervertebral disk (IVD) regeneration. This technique integrated a computer with capable of 3D movement allowing precise motion and control over the polymer scaffold resolution. IVD structures were designed using computer-aided design resemble natural structure. Degradable polyurethane (PU) used as an elastic construct mimic nature native tissue deposited at controlled rate ultra-fine...
The objective of this study was to examine the impact mechanical loading on solute transport in porcine temporomandibular joint (TMJ) discs using electrical conductivity method. conductivity, as well ion diffusivity, TMJ determined under confined compression with 3 strains 5 disc regions. average over regions (mean ± SD) at 0% strain 3.10 0.68 mS/cm, decreased 2.76 0.58 mS/cm (-11.0%) 10% strain, and 2.38 0.55 (-22.2%) 20% compressive strain. Correspondingly, relative diffusivity 0.273...
Structured Abstract Objectives To investigate the intrinsic viscoelastic shear properties in porcine TMJ discs. Materials and methods Twelve fresh discs from young adult pigs (6–8 months) were used. Cylindrical samples (5 mm diameter) with uniform thickness (~1.2 mm) prepared five regions of disc. Torsional tests performed under 10% compressive strain. Dynamic was applied two methods: 1) a frequency sweep test over range 0.1–10 rad/s constant strain amplitude 0.05 rad 2) 0.005–0.15 at 10...
The mechanical properties of the soft palate can be associated with breathing abnormalities. Dorsal displacement (DDSP) is a naturally occurring equine disorder caused by caudal edge palate. Snoring and more serious, sometimes life-threatening, condition called obstructive sleep apnea (OSA) are forms sleep-related disorders in humans which may involve goal this study was to investigate effect injecting protein crosslinker genipin into modify its for treatment DDSP potential implications...
The Food and Drug Administration (FDA) is responsible for protecting public health by regulating medical devices, radiation-emitting electronic drugs, biologics, food, tobacco, cosmetics. After a product reaches the market, Agency continues to evaluate product's safety monitoring adverse events. FDA's Center Devices Radiological Health facilitates reporting of device events complaints manufacturers, importers, healthcare facilities, general help FDA identify potential signals and/or improve...
The precise mechanical properties of many tissues are highly dependent on both the composition and arrangement nanofibrous extracellular matrix. It is well established that collagen nanofibers exhibit a crimped microstructure in several such as blood vessel, tendon, heart valve. This fiber results classic non-linear ‘J-shaped’ stress strain curve characteristic these tissues. Synthetic biomimetic fibrous materials with similar to natural demonstrate following work describes nanofabrication...
The temporomandibular joint (TMJ) is a load-bearing consisting of the condyle mandibular bone, fossa eminence temporal and fibrocartilaginous disc wedged in between bone surfaces (Figure 1A). TMJ serves to distribute stress, lubricate movement, protect articular joint. viscoelastic material two principle phases: solid matrix composed mainly collagen proteoglycan, fluid phase primarily comprised interstitial fluid.
Lessons learned from evaluating previous failures are crucial when engineering future products. As engineered products increase in complexity, their failure modes also increase. In this article, we examine several safety case studies as they relate to medical devices and discuss how these lessons could be applied device design. Ultimately, through detailed reporting thorough discussions of mishaps, product can improved.