About
Contact & Profiles
A5042484998
Research Areas
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
Yale University
2024
Autoimmune diseases, among the most common disorders of young adults, are mediated by genetic and environmental factors. Although CD4 + FOXP3 regulatory T cells (T regs ) play a central role in preventing autoimmunity, molecular mechanism underlying their dysfunction is unknown. Here, we performed comprehensive transcriptomic epigenomic profiling autoimmune disease multiple sclerosis (MS) to identify critical transcriptional programs regulating human autoimmunity. We found that up-regulation...
10.1126/scitranslmed.adp1720
article
EN
Science Translational Medicine
2024-08-28
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