A5101800376- Mosquito-borne diseases and control
- Malaria Research and Control
- Monoclonal and Polyclonal Antibodies Research
- Invertebrate Immune Response Mechanisms
- Tuberculosis Research and Epidemiology
- RNA and protein synthesis mechanisms
- Reproductive Health and Technologies
- Prenatal Screening and Diagnostics
- Immunodeficiency and Autoimmune Disorders
- Toxoplasma gondii Research Studies
- Osteomyelitis and Bone Disorders Research
- Veterinary Orthopedics and Neurology
- Advanced biosensing and bioanalysis techniques
- Reproductive Biology and Fertility
- Insect symbiosis and bacterial influences
- Assisted Reproductive Technology and Twin Pregnancy
- Cell Adhesion Molecules Research
- Autophagy in Disease and Therapy
- Orthopedic Infections and Treatments
- Gastric Cancer Management and Outcomes
- Studies on Chitinases and Chitosanases
- Helicobacter pylori-related gastroenterology studies
- Biochemical and Molecular Research
- Gastrointestinal disorders and treatments
- Mycobacterium research and diagnosis
The University of Texas at Austin
2024-2025
Central Drug Research Institute
2023-2024
All India Institute of Medical Sciences Bhopal
2007
All India Institute of Medical Sciences
2007
All India Institute of Medical Sciences Raipur
2007
Safdarjang Hospital
2004
Vardhman Mahavir Medical College & Safdarjung Hospital
2004
Protozoan parasites of the genus Plasmodium cause malaria and involve infection multiple hosts cell types during life cycle. Producing sexually fit gametocytes is essential for transmitting parasite into an anopheline mosquito vector. After uptake parasites, male undergo three rounds DNA replication to produce eight nucleated flagellar gametes. Here, we report that actin-like proteins Alp5a Alp5b are involved in segregation gametogenesis. The Plasmodium-specific paralogous genes superimposed...
Mycobacterium tuberculosis poses a serious challenge for human health, and new antibiotics with novel targets are needed. Here we demonstrate that an acylaminooxadiazole, MBX-4132, specifically inhibits the trans-translation ribosome rescue pathway to kill M. tuberculosis. Our data MBX-4132 is bactericidal against multiple pathogenic mycobacterial species kills in macrophages. We also show acylaminooxadiazole activity antagonized by iron but potentiated zinc. transcriptomic reveal...
Plasmodium sporozoites are the infective forms of malaria parasite in mosquito and vertebrate host. Gliding motility allows to migrate invade salivary glands mammalian hosts. Motility invasion powered by an actin-myosin motor complex linked glideosome, which contains glideosome-associated proteins (GAPs), MyoA myosin A tail-interacting protein (MTIP). However, role several involved gliding remains unknown. We identified that S14 gene is upregulated sporozoite from transcriptome data yoelii...
SUMMARY Mycobacterium tuberculosis poses a serious challenge for human health, and new antibiotics with novel targets are needed. Here we demonstrate that an acylaminooxadiazole, MBX-4132, specifically inhibits the trans -translation ribosome rescue pathway to kill M. . Our data MBX-4132 is bactericidal against multiple pathogenic mycobacterial species kills in macrophages. We also show acylaminooxadiazole activity antagonized by iron but potentiated zinc. transcriptomic reveals...
Abstract The human malaria parasite Plasmodium falciparum genome is among the most A + T rich, with low complexity regions (LCRs) inserted in coding sequences including those for proteins targeted to its essential relict plastid (apicoplast). Replication of apicoplast (plDNA), mediated by atypical multifunctional DNA polymerase PfPrex, would require additional enzymatic functions lagging strand processing. We identified an apicoplast-targeted, [4Fe–4S]-containing, FEN/Exo (PfExo) a long LCR...
Abstract Plasmodium sporozoites are the infective forms of malaria parasite in vertebrate host. Gliding motility allows to migrate and invade salivary gland hepatocytes. Invasion is powered by an actin-myosin motor complex linked glideosome. However, gliding role several glideosome-associated proteins (GAPs) poorly understood. In silico analysis a novel protein, S14, which uniquely upregulated sporozoites, suggested its association with proteins. We confirmed S14 expression using real-time...