Pneumococcal colonization and carriage

• DOI: 10.1007/bf03399438
• Publication Date: 2018-02-01T10:22:35Z
• Authors: Claire Chewapreecha; Simon R. Harris; Nicholas J. Croucher; Claudia Turner; Pekka Marttinen; Lei Cheng; Alberto Pessia; David M. Aanensen; S Salt- Er; Alison E. Mather; Andrew J. Page; David Harris; François Nosten; David Goldblatt; Jukka Corander; Julian Parkhill; Paul Turner; Stephen D. Bentley; Bhim Gopal Dhoubh...; Lay‐Myint Yoshida; Hanh T. H. Nguyen; Le Huu Nhat Minh; Huong Thi Le; Michio Yasunami; Motoi Suzuki; Konosuke Morimoto; Dinh Kha Dang; Koya Ariyoshi; Adam Finn; Emily Nicoli; Begonia Morales‐Aza; Robert E. Holland; Luís Januário; Barry Vipond; Peter Muir; Fernanda Rodrigues; Erida Gjini; Carina Valente; Raquel Sá‐Leão; Geovana Oliveira ...; Carlos G. Grijalva; Marie R. Griffin; Kathryn M. Edwards; John V. Williams; Ana M. Gil; Héctor Verástegui; Stella M. Hartinger; Jorge E. Vidal; Keith P. Klugman; Claudio F. Lanata; Rama Kandasamy; Meeru Gurung; Susan Ndimah; Ajit Thapa; N Adiakhari; David R. Murdoch; Dominic F. Kelly; Shrijana Shrestha; Stephen Thorson; Jason Hinds; Andrew J. Pollard; Olivier le Polain...; Stefan Flasche; David Prieto‐Merino; W. John Edmunds
• Keywords: Carriage; Multilocus sequence typing

Invited Lecture AbstractsISPPD-0534 Pneumococcal Colonization and Carriage: GENOMICS AND PNEUMOCOCCAL EPIDEMIOLOGY IN THE NASOPHARYNXC. Chewapreecha1, S.R. Harris1, N.J. Croucher2, C. Turner3, P. Marttinen4, L. Cheng5, A. Pessia5, D. Aanensen6, S.J. Salter1, A.E. Mather1, A.J. Page1, F. Nosten7, Goldblatt8, J. Corander5, Parkhill1, S.D. Bentley11Pathogen genomics, The Wellcome Trust Sanger Institute, Cambridge, United Kingdom; 2Center for Communicable Disease Dynamics, Harvard School of Public Health, Boston, USA; 3Cambodia-Oxford Medical Research Unit, Angkor Hospital Children, Siem Reap, Cambodia 4Department Information Computer Science, Aalto University, Helsinki, Finland; 5Department Mathematics Statistics, University 6Department Infectious Epidemiology, Imperial College London, 7Shoklo Malaria Mahidol-Oxford Tropical Medicine Tak, Thailand; 8Immunobiology Institute Child Health KingdomHomologous recombination is one the main evolutionary forces affecting Streptococcus pneumoniae. highly recombinogenic nature this species allows introduction genetic material with selective advantages in carriage, state that a prerequisite development pneumococcal invasive diseases. To study impact on evolution carriage population, whole genome sequencing was used to characterize 3,085 isolates from 2.4 km2 Thai refugee camp collected over 3-year period. This high sampling density allowed us characterized exchanges population at resolution. Recombination ‘hotspots’ showed remarkable consistency between lineages, some which were associated drug resistance. Temporal trends these sites reflected changes antibiotic consumption, suggesting facilitates adaptation changing selection pressures. highest frequencies receipt donation DNA fragments exchanged through homologous observed non-encapsulated implying potential role diversification overall played by non-vaccine target lineages. These findings expand our understanding help inform design future intervention strategies.No conflict interestISPPD-0550 INTERACTIONS BETWEEN STREPTOCOCCUS PNEUMONIAE RESPIRATORY MICROBIOME RELATION TO HEALTHD. Bogaert11The NetherlandsIndividuals differ markedly their susceptibility clinical presentation respiratory infections, despite most young children many adults are colonized bacterial pathogens like reasons individual differences not yet fully understood, but clearly multifactorial. Besides pathogen-related (virulence)-factors, host-related factors immune-status background environmental factors, possible fourth factor might be relevance, i.e. commensal community bacteria ‘hosting’ pathogens. collective genomes inhabitants referred as human microbiome. microbiome contains complexity communities bacteria, individuals even more niches. general has shown crucial an appropriate immune system mucosal barriers, prevention pathogen adherence expansion. We studied composition microbiota upper tract different age-groups relation disease characteristics. complex niche-specific bacteria. Even within tract, differs depending exact anatomical location. Furthermore, varies host age, season, infant feeding, viral presence. Moreover, data suggest correlation presence abundance specific stability microbiota, well infections. Finally, clear evidence been found patterns interactions central Streptococci.No interest