Repeatability of vessel density measurements using optical coherence tomography angiography in retinal diseases

• DOI: 10.1111/aos.13972_231
• Publication Date: 2018-12-12T12:15:22Z
• Authors: Min‐Woo Lee; Kyeung‐Min Kim; Hyung‐Bin Lim; Young–Joon Jo; Jung‐Yeul Kim
• Keywords: Repeatability

Aim To analyse the repeatability of vessel density (VD) measurements using optical coherence tomography angiography (OCTA) in patients with retinal diseases. Methods Two consecutive VD OCTA were analysed prospectively diseases (diabetic macular oedema (DME), vein occlusion (RVO) oedema, epiretinal membrane (ERM), wet age-related degeneration (AMD)). The intraclass correlation coefficient (ICC), variation (CV) and test-retest SD assessed, linear regression analyses conducted to identify factors related repeatability. Results A total 134 eyes involving 20 DME, 44 RVO 50 ERM AMD. mean age was 64.9 years, best-corrected visual acuity (BCVA) 0.24. central thickness (CMT) 391.6 µm, ganglion cell-inner plexiform layer (GC-IPL) 61.4 µm. In all four diseases, ICC CV full 0.812 6.72%, respectively. Univariate showed that BCVA (B, 8.553; p=0.031), signal strength −1.688; p=0.050), CMT 0.019; p=0.015) GC-IPL −0.103; p=0.001) significant affected Multivariate these a result for thickness. Conclusions Measurements relatively good various BCVA, strength, repeatability, so should be considered when analysing VD.