The effects of preferential deposition of histamine in the human airway.

• DOI: 10.1164/arrd.1978.117.3.485
• Publication Date: 1978-03-01
• Authors: R. E. Ruffin; Myrna Dolovich; Ronald K. Wolff; Michael T. Newhouse
• Keywords: Airway obstruction; Deposition

Two inhalation techniques were performed to obtain airway and diffuse deposition of histamine aerosol. A radiotracer method was used confirm the patterns aerosol measure dose in airways. In 5 subjects effect cumulative doses given either centrally or diffusely airways measured. Histamine deposited predominantly large more effective increasing obstruction that aerosol, suggesting receptors mediating action reside mainly